Background: Patients with fever of unknown origin (FUO) are elusive and challenging clinical cases. Timely detection and identification of blood borne pathogen is one of the most important functions of microbiology laboratory. Objectives: To evaluate the efficacy of BACTEC 9050 in comparison to conventional blood culture for detection of bacterial isolates in clinically suspected cases of fever...

BACKGROUND Few reports have examined the viral aetiology of fever of unknown origin (FUO). OBJECTIVE This study determined the prevalence of human herpes virus (HHV) DNA in blood of Chinese patients with classic FUO using the polymerase chain reaction (PCR) and explored the possible role of HHV. STUDY DESIGN Blood samples were collected from 186 patients (151 children, 35 adults) with class...

Visceral leishmaniasis is the second most common cause of fever of unknown origin in our study. This disease is not common in adults, although it's endemic among the pediatric age group. The majority of the affected individuals were young. High grade spiking fever, chills and splenomegaly were unique findings. Other common findings were neutropenia, anemia, abnormal liver function tests, st...

BACKGROUND Fever of unknown origin (FUO) has always been a challenging problem for physicians since it was first reported half a century ago. This study aimed to investigate the clinical features of FUO and to compare the clinical significance of the classical diagnostic criteria and the Chinese revised diagnostic criteria of FUO. METHODS We retrospectively collected a series of 140 patients ...

In 30% of patients with fever or inflammation of unknown origin (FUO/IUO), the cause is eventually found to be a rheumatologic disease such as autoimmune or granulomatous disease or vasculitis. Most of these patients suffer from an uncommon presentation of a common disease, instead of an uncommon disease. We demonstrate the diagnostic challenge with several cases. The workup of FUO is based on ...

OBJECTIVE To report a rare case of brucellosis with myelo-dysplastic syndrome (MDS). CLINICAL PRESENTATION AND INTERVENTION A 70-year-old woman presented with pancytopenia and fever of unknown origin (FUO). The initial diagnosis was brucellosis; the woman was treated with doxycycline and rifampin against Brucella melitensis but was later diagnosed as suffering from MDS. She was immediately tr...

Disseminated tuberculosis is an important differential diagnosis for fever of unknown origin (FUO) and it can present with hepatosplenomegaly and lymphadenopathy and may have meningitis and with hematological abnormalities including pancytopenia or a leukemoid reaction. We report the case of a 13-year old male who presented with fever, weight loss, pallor and massive splenomegaly with pancytope...

Fever of unknown origin (FUO) remains to be a challenge despite advancement in diagnostic technologies and procedures. FUO is considered when fever presents intermittently without an explanation. It has been linked to various etiologies, which makes it difficult to diagnose. We present the case of 18-month-old female with recurrent fever, splenomegaly, abdominal pain, and constipation. The work...

Background Fever of unknown origin (FUO) is a diagnostic challenge in children, especially differentiation of systemic onset juvenile idiopathic arthritis (SOJIA), an autoinflammatory syndrome associated with uncontrolled activation of phagocytes. In this study, we analysed the relevance of myeloid related proteins 8 and 14 (MRP8, MRP14), two endogenous activators of toll-like receptor 4, for e...