Introduction: Growth and proliferation of the remaining microorganisms within the root canals may destroy the surrounding tissue of the root and leads to periapical lesion. Consequently, the complete elimination of microorganisms from the root canal is a n important goal of endodontic therapy. Endodontic sealers do not provide complete seal in root canal system, and micro spaces have always rem...

BACKGROUND The aim of the present study is to evaluate and compare the cytotoxic effects of eight root canal sealers (BioRoot RCS, TotalFill BC Sealer, MTA Fillapex, Sealapex, AH Plus, EasySeal, Pulp Canal Sealer, N2) on immortalized human gingival fibroblasts over a period of 24, 48 and 72 hours. MATERIAL AND METHODS Immortalized human gingival fibroblast-1 HGF-1 (ATCC CRL-2014) were incubat...

Background. Further studies on the adhesion properties of MTA-based materials seem necessary due to their growing use in endodontic treatment. This research aimed to assess the effect of retreatment on the bond strength of MTA-based (MTA Fillapex) and epoxy resin-based (AH Plus) sealers. Methods. ProTaper rotary files were applied to prepare the root canals of 80 human mandibular premolars. The...

UNLABELLED Mineral Trioxide Aggregate (MTA) is a calcium silicate-based material. New sealers have been developed based on calcium silicate as MTA Fillapex and MTA Plus. OBJECTIVE The aim of this study was to evaluate biocompatibility and bioactivity of these two calcium silicate-based sealers in culture of human dental pulp cells (hDPCs). MATERIAL AND METHODS The cells were isolated from t...

Background. Maximum sealing ability or adhesion of endodontic sealers can be achieved after effective removal of the smear layer. Endodontic irrigants assist in adequate removal of the smear layer, improving the retention mechanism. The aim of this study was to evaluate the effect of two different root canal irrigation solutions (5.25% NaOCl followed by 17% EDTA and QMix) on the apical sealing ...