A new kind of percolation problem is described which differs from ordinary percolation theory in that it automatically finds the critical points of the system. The model is motivated by the problem of one fluid displacing another from a porous medium under the action of capillary forces, but in principle it may be applied to any kind of invasion process which proceeds along a path of least resi...

Interstitial flow emanates from tumors into the microenvironment where it promotes tumor cell invasion. Fibroblasts are key constituents of the tumor stroma that modulate the mechanical environment by matrix remodeling and contraction. Here, we explore how interstitial fluid flow affects fibroblast-tumor cell interactions. Using a 3-dimensional invasion assay and MDA-MB-435S cells cocultured wi...

Brain tumor invasion leads to recurrence and resistance to treatment. Glioma cells invade in distinct patterns, possibly determined bymicroenvironmental cues including chemokines, structural heterogeneity, and fluid flow. We hypothesized thatfloworiginating frompressure differentials between the brain and tumor is active in glioma invasion. Using in vitromodels, we show that interstitial flow p...

Interstitial flow emanates from tumors into the microenvironment where it promotes tumor cell invasion. Fibroblasts are key constituents of the tumor stroma that modulate the mechanical environment by matrix remodeling and contraction. Here, we explore how interstitial fluid flow affects fibroblast–tumor cell interactions. Using a 3-dimensional invasion assay and MDA-MB-435S cells cocultured wi...

Brain tumor invasion leads to recurrence and resistance to treatment. Glioma cells invade in distinct patterns, possibly determined by microenvironmental cues including chemokines, structural heterogeneity, and fluid flow. We hypothesized that flow originating from pressure differentials between the brain and tumor is active in glioma invasion. Using in vitro models, we show that interstitial f...

Preterm birth remains the leading cause of perinatal mortality and morbidity. Evidence suggests that intrauterine infection plays an important role in the pathogenesis of preterm labor. This article reviews the clinical data supporting this theory and the cellular and biochemical mechanisms by which intrauterine infection may initiate uterine contractions. The clinical and laboratory methods of...

background accurate and rapid diagnosis of bacterial arthritis is not always possible in unvaccinated (streptococcus pneumoniae and haemophilus influenzae type b) children in iran. objectives searching the staphylococcal superantigen (entrotoxin a, b, c and tsst1) in synovial fluid of cases with inflammatory arthritis. patients and methods this cross sectional study was implemented in the pedia...