In bone disorders infections are common. The concentration of majority of antibiotics is very low in the bone tissue. A high local dose can be obtained from the ciprofloxacin-loaded hydroxyapatite nanoparticles. The present study is aimed at developing the use of hydroxyapatite and zinc-doped hydroxyapatite nanoparticles as a carrier for ciprofloxacin drug delivery system. The ciprofloxacin-loa...

BACKGROUND Ceramic hydroxyapatites and non-ceramic hydroxyapatites have been used extensively as alloplastic materials for bone reconstruction. However, different forms of hydroxyapatite induce different types of tissue response. METHODS Human gingival fibroblasts (FMM1 cells) were used to analyze ceramic and non-ceramic hydroxyapatite biocompatibility. The cells were grown on surfaces covere...

Hydroxyapatite (Ca10(PO4)6(OH)2) is one of the implants materials with medical applications due to its higher biocompatibility. The hydroxyapatite found complete utilization after proper preparation of composite. The influence of zirconia (ZrO2) on the phase composition and on mechanical properties of hydroxyapatite-zirconia composites has been previous investigated and reported. Hierarchical c...

PURPOSE HER2 overexpression has been associated with a poor prognosis and resistance to therapy in breast cancer patients. We are developing molecular probes for in vivo quantitative imaging of HER2 receptors using near-infrared (NIR) optical imaging. The goal is to provide probes that will minimally interfere with the studied system, that is, whose binding does not interfere with the binding o...

B. MENNESSON∗,††, N. SCOTT†, T. TEN BRUMMELAAR†, G. BRYDEN∗, N. TURNER∗, O. ABSIL‡, R. MILLAN-GABET§, V. COUDE DU FORESTO¶, J. C. AUGEREAU‖, S. RIDGWAY∗∗, J. LEBRETON‖ and L. MARION‡ ∗Jet Propulsion Laboratory, California Institute of Technology 4800 Oak Grove Drive, Pasadena CA 91109-8099, USA †Center for High Angular Resolution Astronomy Georgia State University Mt. Wilson, CA 91023, USA ‡Dep...

Four novel bis-boronic acid compounds were synthesised via copper catalysed azide-alkyne cycloaddition (CuAAC) reactions. Glucose selectivity was observed for a particular structural motif. Moreover, a new glucose selective fluorescent sensor was designed and synthesised as a result.

Adsorption of Streptococcus mutans on hydroxyapatite and chemically treated hydroxyapatite was studied. Zeta potentials of the surfaces were measured. Chemically treated hydroxyapatite gave higher zeta potentials and lower S mutans adsorption.