BACKGROUND Dry eye disease (DED) affects millions of people worldwide. There are a variety of new treatments beyond traditional therapies such as preservative free artificial tears. Here, we conduct a survey to identify the most common treatments used among specialists and assess their interest in newer therapies. METHODS An international survey was distributed to dry eye researchers and expe...

PURPOSE Corticosteroids are efficient anti-inflammation treatments. However, there are still arguments on whether it should be used in keratitis. This study was to observe the effect of corticosteroids on keratocytes both in normal condition and inflammation status in vitro. METHODS Rat keratocytes were cultured and used for examination. 10 μg/ml lipopolysaccharide (LPS) was used to establish...

OBJECTIVES To compare topical interleukin 1 receptor antagonist (IL-1ra) to steroid treatment following photorefractive keratectomy (PRK) in rabbit eyes. METHODS Our study is a randomized, investigator-masked study that was approved by the Institutional Animal Care and Use Committee. Following standard PRK, 48 eyes of 24 rabbits were divided into 5 arms: 4 treatment arms and 1 control arm. Th...

Corneal deposits after the topical use of ofloxacin in two children with vernal keratoconjunctivitis Topical fluoroquinolones are broad spectrum, bactericidal agents with activity against both Gram positive and Gram negative corneal pathogens. Single drug administration with topical fluoroquinolones has been effectively used in treatment of bacterial ulcerative kera-titis. The drugs are safe, b...

PURPOSE To determine the effect of keratoconjunctivitis sicca, induced by botulinum toxin-B (BTX-B), on the inflammatory cytokine gene expression in the lacrimal gland (LG). And to determine the effect of various topical anti-inflammatory agents on the resulting cytokine levels. METHODS Forty-two mice (eight-week-old, female, CBA/J) were divided into six groups. Four groups were injected with...

Dear Editor, Paecilomyces, which is found in soil and decaying vegetables, is a rare pathogen causing local and systemic infections [1]. We report a rare case of recurrent Paecilomyces keratitis 5 years after Jones tube placement in conjunctivodacryocystorhinostomy (CDCR). A 69-year-old woman was referred by a local ophthalmologist for the management of presumed fungal keratitis in the left eye...