Fibroblast growth factor receptor-2 (FGFR-2) plays an important role in tumorigenesis. In thyroid cancer it has been observed a FGFR-2 down-modulation, but the role of this receptor has not been yet clarified. Therefore, we decided to examine the expression of both FGFR-2 isoform, FGFR-2-IIIb and FGFR-2-IIIc, in different histological thyroid variants such as hyperplasia, follicular adenoma and...

HYPOTHESIS Dipeptidyl aminopeptidase IV (DPP IV) activity in cytological samples from a follicular thyroid tumor is the most sensitive and specific indicator for the detection of follicular carcinoma of the thyroid gland. Dipeptidyl aminopeptidase IV activity is independent of cytological characteristics and superior to other clinical findings. DESIGN AND PATIENT SELECTION: Among the patients s...

Thyroid carcinoma is a common endocrine cancer with a favorable prognosis if subjected to timely treatment. However, the clinical identification of follicular thyroid carcinoma (FTC) among patients with benign thyroid nodules is still a challenge. Preoperative fine needle aspiration-based cytology cannot always differentiate follicular carcinomas from benign follicular neoplasias. Because curre...

In this study, 105 cases of thyroid lesions were evaluated to assess the role of HBME-1, cytokeratin-19 (CK-19), galectin-3 in distinguishing benign from malignant thyroid lesions. Thirty-seven papillary, 10 follicular, 6 medullary, 1 mixed medullary follicular cell carcinoma, 3 poorly differentiated carcinoma, 18 adenomatous nodular hyperplasia, 30 follicular adenoma cases were included in the...

Thyroid follicular epithelial cell–derived cancer includes papillary carcinoma, Hürthle cell poorly differentiated thyroid cancer, and anaplastic carcinoma. Although the incidence of has increased over past 30 years, there not been a significant increase in patient mortality. Use increasingly sensitive detection methods such as high-resolution imaging enabled earlier better characterization mal...

Since the introduction of fine needle aspiration biopsy (FNAB) in the 1970's, a preoperative diagnostic technique for thyroid follicular carcinoma has long been awaited. Many markers that distinguish follicular carcinomas from adenomas have been reported; however, most of them have not been confirmed to be beneficial for clinical use. Trefoil factor 3 (TFF3) is a relatively new family of peptid...

OBJECTIVES/HYPOTHESIS The objective was to determine clinical features and clinical outcomes for pediatric thyroid carcinoma. STUDY DESIGN Cross-sectional analysis of national cancer database. METHODS The Surveillance, Epidemiology, and End Results database (1988-2000) was surveyed, extracting all cases of pediatric thyroid carcinoma. Clinical features including age, gender, tumor type, tum...

UNLABELLED Thyroid-like follicular carcinoma of the kidney (TLFC), a rare neoplasm with low malignant potential, is histologically similar to primary thyroid follicular carcinoma, but characteristically lacks thyroid immunohistochemical markers. We report a case of 34-year old patient with nephrolithiasis. Ultrasound revealed hepatorenal cysts consistent with adult type polycystic kidney diseas...

OBJECTIVE Endothelin-1 (ET-1) may play a role in carcinogenesis. ET-1 axis is overexpressed in thyroid carcinoma. We investigated the expression and the production of ET-1 by thyroid cancer cells as well as the effect of ET-1 receptor antagonism on cell proliferation. DESIGN Human papillary and follicular thyroid carcinoma cell lines were cultured. MEASUREMENTS (i) Prepro-ET-1, ET-1 recepto...

Objective: The study evaluated the prevalence and progression of different thyroid tumors in patients who referred to Shahid Sadoughi Hospital during 2005 to 2013, Yazd, Iran. Materials and Methods: In this retrospective follow-up study, cytopathological data of patients suffering from thyroid masses was collected during 2005-2013. Age and sex of patients were recorded. Results: Totally, 2055...