ABSTRACT: This article provides an overview on Development and Validation of Force degradation study with Stability Indicating Methods (SIMs) for drug substances. Different stress conditions (hydrolysis, oxidation, thermal, photolytic conditions) are applied to drugs compounds during a process known as forced degradation, result, various products created. The major purpose these investigations ...

Restorative dental materials must be produced with special characteristics because they are operating in a medium environment different humidity and temperature. These day-to-day factors play an important role the lifetime of such restorative materials. Resin composites have been by far most successful applications meeting several stringent design requirements that difficult to achieve homogene...

Hydroxyl radicals (OH) are involved in the development of reperfusion injury and myocardial failure. In the acute phase of the OH-mediated diastolic dysfunction, increased intracellular Ca levels and alterations of myofilaments may play a role, but the relative contribution of these systems to myocardial dysfunction is unknown. Intact contracting cardiac trabeculae from rabbits were exposed to ...

This study focuses on the characterization of photocatalytic TiO2 coatings using Kelvin probe force microscopy. While most photocatalytic experiments are carried out at a macroscopic scale, Kelvin probe force microscopy is a microscopic technique that is surface sensitive. In order to link microscale results to macroscopic experiments, a simple method to establish the relation between Kelvin pr...

the track stiffness experienced by a train will vary along the track. sometimes the stiffness variation may be very large within a short distance. one example is when an unsupported sleeper is hanging in the rail. track stiffness is then, locally at that sleeper, very low. at insulated joints the bending stiffness of the rail has a discontinuity implying a discontinuity also of the track stiffn...

in recent years, different damage indexes have been introduced in engineering literature. the most prominent one among other counterparts is the 1985 park and ang's damage index (dipa), which demonstrates well calibration against experimental results. hence, it has traditionally had broad application in the field of structural engineering. commonly, in dipa relevant parameters are assessed...

the “driving force - pressure - state - impact – response” modeling framework isadopted to consider the formation mechanisms of environmental risks and the requirements ofecological environment protection. moreover, a systematical index system and evaluation model forthe measurement of the coastal ecological security level is put forward in this paper to assess thestate of coastal ecological en...

A simple and rapid stability indicating method based on capillary zone electrophoresis has been developed and validated for the analysis of buserelin (BUS). The best separations were achieved by using a bare fused silica capillary (75 m i.d.; 65.5 cm total, 57.0 cm effective length), phosphate buffer (pH = 3.00; 26.4 mM), at 35 °C. The sample was hydrodynamically injected at 50 mbar for 5 seco...