Aiming to contribute drug pre-formulation, new eutectic mixtures were developed. Thymol, coumarin, or quaternary ammonium chlorides as excipients, combined with the active pharmaceutical ingredients (APIs) acetylsalicylic acid, acetaminophen, ibuprofen, ketoprofen, lidocaine. Their solid-liquid equilibrium (SLE) binary phase diagrams measured study eventual separation between compounds, prevent...

mulation and in many cases the bioavailability of drug from tablets has received considerable attention. As part of the efforts to reach international harmonization of pharmaceutical excipients, the Joint Conference on Excipients identified starch as one of the top 10 excipients (1). Starch is a multipurpose excipient in tablet formulation, and it is used as a binder, disintegrant, and filler (...

Orally disintegrating tablets (ODTs) are capable of turning quickly into a liquid dosage form in contact with the saliva, thus possessing the advantages of both the solid dosage forms particularly stability and liquid dosage forms specially ease of swallowing and pre-gastric absorption of drug. The aim of this study was to prepare a novel matrix-type buccal fast disintegrating ibuprofen tablet ...

it has been observed that most of the chemical entities have high lipophilicity and poor aqueous solubility, which result in poor bioavailability. in order to improve the bioavailability, the release behavior of such drugs should be improved. although there are numerous techniques to handle solubility related issue, but they are expensive due to involvement of complicated equipments, advanced m...

The excipients and additives in drug formulations have been described as inert because they do not have an active role in the prevention or treatment of particular ailments. This has led to the misconception among physicians, pharmacists, drug manufacturers and the public that excipients are harmless and unworthy of mention. In fact, pharmacists are allowed to substitute drug formulations, with...

Different types of factorial experimental designs can be used in compatibility studies of drug development, where many different factors and their interactions should be evaluated to predict their effects on the degradation of the drug substance under study. All possible main and interaction effects of different potential excipients that can constitute the drug product should be evaluated in or...

This paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). Tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

This study describes development and subsequent validation of a reversed phase high performance liquid chromatographic (RPHPLC) method for the estimation of ursodeoxycholic acid used to solubilize cholesterol gallstones, in conventional tablet dosage formulation and in prepared dosage form. The chromatographic system was achieved in a BDS Hypersil C8 column (Thermo, 250mm x 4.6 mm, 5 μ) with an...

Article history: Received on: 09/07/2013 Revised on: 16/09/2013 Accepted on: 03/10/2013 Available online: 31/10/2013 The aim of the study was to develop a formulation of Ticagrelor 90 mg tablets that is equivalent to the reference product using similar excipients to match the in-vitro dissolution profile. A compressed coated tablet was formulated consisting of Ticagrelor and excipients conformi...