This paper presents many different parallel formulations of the A*/Branch-and-Bound search algorithm. The parallel formulations primarily differ in the data structures used. Some formulations are suited only for shared-memory architectures, whereas others are suited for distributedmemory architectures as well. These parallel formulations have been implemented to solve the vertex cover problem a...

       Survivin, an inhibitor of apoptosis protein is highly expressed in most cancers and considered as an attractive target for cancer antisense therapy. To vectorize antisense molecules, cationic nanoliposomes are generally used; however, their complexes are too instable, during shelf-life and upon exposure to blood components and extracellular matrix, to be used in-vivo. The present study a...

The aim of the present investigation is to develop topical gel and cream formulations of psoralen for enhancing its transport through the skin, with the goal to shorten the delay between drug application and UVA irradiation. In our first studies, oil-in-water (O/W) creams of psoralen (0.05% concentration) were prepared using Apifil (PEG-8 Beeswax) and Plurol Stearique WL 1009 as emulsifying age...

It is well known that selecting a good Mixed Integer Programming (MIP) formulation is crucial for an e↵ective solution with state-of-the art solvers. While best practices and guidelines for constructing good formulations abound, there is rarely a systematic construction leading to the best possible formulation. We introduce embedding formulations and complexity as a new MIP formulation paradigm...

Lipid-based formulations encompass a diverse group of formulations with very different physical appearance, ranging from simple triglyceride vehicles to more sophisticated formulations such as self-emulsifying drug delivery systems (SEDDS). Lipid-based drug delivery systems may contain a broad range of oils, surfactants, and co-solvents. They represent one of the most popular approaches to over...

The classical time-indexed 0–1 linear programming formulations for the resource-constrained project scheduling problem involve binary variables indicating whether an activity starts precisely at or before a given time period. In the literature, references to less classical “on/off” formulations, that involve binary variables indicating whether an activity is in progress during a time period, ca...

An extended formulation of a polytope is a linear description of this polytope using extra variables besides the variables in which the polytope is defined. The interest of extended formulations is due to the fact that many interesting polytopes have extended formulations with a lot fewer inequalities than any linear description in the original space. This motivates the development of methods f...

the pharmacokinetic properties of amoxicillin and clavulanic acid when used alone or in combination may be different and show interaction between these two agents that might decrease the absolute bioavailability of clavulanic acid. in an open, randomized, replicated latin square under fasting condition, pharmacokinetics of new formulations of amoxicillin/clavulanic acid were compared with a ref...

In the history of insulin therapy some milestones are present. In 1921, the young physician Frederick Banting (1881-1941) and the forth year medical student Charles Best (1899-1978), working in the laboratory of Prof. McLeod in the Toronto University, found the final link in a series of studies begun in 1916 by other researchers that guessed the pancreas secretetion of substance, already named ...

Column generation has become a powerful tool in solving large scale integer programs. It is well known that most of the often reported compatibility issues between pricing subproblem and branching rule disappear when branching decisions are based on imposing constraints on the subproblem’s variables. This can be generalized to branching on variables of a so-called compact formulation. We constr...