BACKGROUND Hip fracture contributes to increased morbidity and mortality in the elderly population. As the average age of the population is increasing, the burden of hip fracture on the health-care system is a growing challenge. The highest incidence of hip fracture worldwide has been reported from Scandinavia in fact from Oslo the capital of Norway. During the last decades, efforts have been u...

OBJECTIVE To measure the prevalence of primary drug prevention of fractures due to osteoporosis in patients admitted to a tertiary teaching hospital, in a medium-sized city, admitted with osteoporotic fractures. Moreover, to identify the incidence of prescribing secondary prophylaxis after the first fracture event. At the same time, the prevalence of risk factors for such fractures as described...

Strategies to reduce fracture risk must be based on the understanding of the mechanisms that underline the increased incidence of fractures with age and with bone diseases that reduce bone stock. There is evidence that in addition to bone minerals density, other factors influence bone strength. This study reviews the biomechanical aspects of age-related fractures, including the interacting role...

In 1997, when I reported on the progress of the “osteoporosis revolution,” fi ve topics were emphasized: genetics, local factors, bone mass measurements, biochemical markers, and prevention and therapy. During the past 10 years there has been substantial progress in all of these areas, but the revolution is by no means over. This review summarizes our current concepts of epidemiology, pathogene...

The diagnosis of osteoporosis centres on the assessment of bone mineral density (BMD). Osteoporosis is defined as a BMD 2.5 SD or more below the average value for premenopausal women (T score < -2.5 SD). Severe osteoporosis denotes osteoporosis in the presence of one or more fragility fractures. The same absolute value for BMD used in women can be used in men. The recommended site for diagnosis...

BACKGROUND Bone mineral density (BMD) has been shown to be a consistent and independent risk factor for distal radius fracture. Inconsistent data have been reported on the association between BMD and severity of distal radius fracture. Our primary aim was to explore if there is an association between cortical BMD at the hand and the severity of fragility distal radius fracture. METHODS Consec...

Bone’s fracture resistance relies on its material properties, which can change with aging and disease. The material properties may be altered by changes in bone’s organic matrix via biochemical modifications of collagen, such as non-enzymatic glycation (NEG), which produces crosslinks known as advanced glycation end-products (AGEs). Alterations may also arise from the non-collagenous protein co...

Raman spectroscopy was applied to nail clippings from 633 postmenopausal British and Irish women, from six clinical sites, of whom 42% had experienced a fragility fracture. The objective was to build a prediction algorithm for fracture using data from four sites (known as the calibration set) and test its performance using data from the other two sites (known as the validation set). Results fro...

Prevention of fragility fractures in older people has become a public health priority, although the most appropriate and cost-effective strategy remains unclear. In the present statement, the Interest Group on Falls and Fracture Prevention of the European Union Geriatric Medicine Society, in collaboration with the International Association of Gerontology and Geriatrics for the European Region, ...

With the increasing life expectancy, osteoporosis is becoming a major worldwide health problem. Osteoporotic fragility fractures affect the quality of life and are associated with premature mortality. The magnitude of the disease may become larger in developing countries, particularly in the Middle East where the prevalence of low bone mass is higher than in Western countries. Besides two small...