Afroeudesis Franz and Oreoeudesis Franz, Afrotropical subgenera of Pseudoeudesis Binaghi (Scydmaenini), are elevated to the genus rank and transferred to Cyrtoscydmini. The East Palaearctic genus Nanoscydmus Jałoszyński is reduced to a subgenus of Afroeudesis stat. n., resulting in Afroeudesis (Nanoscydmus) baoshanus (Jałoszyński), comb. n. and Afroeudesis (Nanoscydmus) nepalensis (Jałoszyński)...

The current study involves the evaluation of factors that influence the transcorneal permeation of aqueous drops of aceclofenac ophthalmic formulation through freshly excised goat, sheep, and buffalo corneas. Aceclofenac formulation with different concentrations 0.1-0.5% (w/v) and with different pH and different preservatives, was taken into account. The amount of drug permeated from different ...

In the present work, levofloxacin based microemulsion was developed and its usefulness as topical drug carrier system for anti bacterial activity was investigated. Microemulsion was prepared by phase titration method using oleic acid as oil phase, tween-60 as surfactant and isopropyl alcohol as co-surfactant. Five different formulations were formulated with various amount of the oil, water and ...

Nowadays in orthopedic surgery -in the treatment of bone and soft tissue infectionsthere is an increasing claim for improving biodegradable drug delivery systems that can be easily placed into the site of application instead of the currently applied polymethylmethacrylate (PMMA) bone cements, since PMMA has some undesirable side effects. Therefore the aim of the study was to develop an injectab...

Alaptide, (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, is an original Czech compound; in this paper it is used as an excipient. The investigation deals with the affection of the permeation of indomethacin through full-thickness pig ear skin using a Franz diffusion cell from the donor vehicle of propylene glycol/water (1:1) using nanonized alaptide as a potential transdermal permeation enha...

Genera Stenichnus and Scydmoraphes are distributed in the Northern Hemisphere, with a few rather peculiar species described from South America. Type series of Stenichnus andicola Franz, Scydmoraphes venezolanus Franz and Scydmoraphes peruanus Franz were examined and the first of these species is transferred to Sciacharis Broun, while two new generic names are established to accommodate the two ...

The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effec...

Subgenera of the speciose ant-like stone beetle genus Stenichnus Thomson are revised. The genus is re-classified and only two subgenera are retained: Stenichnus s. str. and Scydmaenichnus Reitter. Two remaining subgenera, Austrostenichnus Franz and Scydmaenilla King, are elevated to the genus rank (the status of Scydmaenilla, originally described as a genus and later reduced to a subgenus of St...

Niosomes, as a kind of drug delivery system, is widely used for the topical lipophilic drugs. Optimization niosomes plays an essential role in enhancing their therapeutic efficiencies. This study aims to prepare optimized niosomal formulation simvastatin (nSIM), member statins, through experiment (Response Surface methodology). Optimized were characterized size, polydispersity index (PDI), entr...

Vesicular drug delivery systems have recently gained attention as a way of improving dosing accuracy for drugs with poor transdermal permeation. The current study focuses on utilization of the natural biocompatible vesicles to formulate vardenafil nanoethosomes (VRD-NE), for the enhancement of their transdermal permeation and bioavailability. Fifteen formulations were prepared by thin-layer eva...