Diabetes is a risk factor for heart failure and cardiovascular mortality with specific changes to myocardial metabolism, energetics, structure, and function. The gradual impairment of insulin production and signalling in diabetes is associated with elevated plasma fatty acids and increased myocardial free fatty acid uptake and activation of the transcription factor PPARα. The increased free fat...

The putative role played by insulin sensitizers in modulating adipose tissue lipolysis in the fasting state was evaluated in obese conscious Zucker rats treated with troglitazone or beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) and compared with nontreated lean and obese animals. The rates of appearance (R(a)) of glycerol and free fatty acid (FFA), primary intra-adipose reesterificatio...

A regulatory role of acute changes in plasma concentration of free fatty acids on glucagon secretion has been suggested. We have studied the effect of such changes on plasma levels of glucagon, insulin, and growth hormone in man. Basal plasma levels of immunoreactive glucagon (IRG) were only slightly raised in 11 healthy subjects when the mean concentration of free fatty acids (FFA) was depress...

The incorporation into triglycerides of l-14Clabeled saturated free fatty acids (FFA) of different chain lengths (CrC,,) was studied using incubation of rat epididymal fat pads in vitro. The results indicate that the rate at which adipose tissue incorporates FFA is dependent on chain length. With very short-chain acids a small amount is directly esterified into triglycerides, but the major port...

the aim of this study was to compare the effects of olive leaf extracts and synthetic antioxidant bht at concentration of 1% at increase the shelf life of rainbow trout fillets in light salted and packed at 4±1 °c that index of peroxide (pv), free fatty acids (ffa), thiobarbituric acid (tba), humidity, ph and sensory evaluation of fillets of rainbow trout kept in the refrigerator at the time of...

background: fatty acids are an important source of energy for muscle contraction, particularly during longtime exercise. the objective of this clinical trail study was to determination effect of heparin infusion on lipids metabolism during submaximal exercise. methods: forty boy students performed astrand ergometery protocol for 20-minute on cycle ergometer in two separate occasions. stage1 wit...

measuring the rate of changes in total polar compounds (tpc) content and polar fractions, the oxidative stability of canola oil during frying process as affected by bene kernel oil (bko, 0.05 and 0.1%) and tert-butylhydroquinone (tbhq, 100ppm) was investigated. it was observed that the tpc content increased linearly with frying time (r2 > 0.98). the canola oil containing the bko (especially 0.1...

The associations between obesity, insulin resistance, and type 2 diabetes mellitus are well documented. Free fatty acids (FFA), which are often elevated in obesity, have been implicated as an important link in these associations. Contrary to muscle glucose metabolism, the effects of FFA on hepatic glucose metabolism and the associated mechanisms have not been extensively investigated. It is sti...