introduction: fasting is an islamic practice, which causes various metabolic changes in fasting individuals. numerous studies have examined different aspects of fasting, but its effect on individuals with different characteristics such as obesity has remained unknown. the impact of fasting on adipose tissue hormones such as leptin and adiponectin is still controversial. in this study, we aimed ...

objective(s):leptin is a novel and interesting hormone for anyone trying to lose weight, but its effects on male gonad structure in longitudinal study is unknown. the present study was designed to explore morphometrical changes of mouse testicular tissue after long-term administration of leptin. materials and methods:thirty healthy mature male mice were randomly assigned to either control (n=15...

background: in this study, we aim to compare insulin and leptin levels in adolescents with or without overweight and in those with or without abdominal obesity. materials and methods: this case-control study was conducted among 486 samples. we randomly selected 243 overweight and an equal number of normal-weight adolescents from among participants of the third survey of a national surveillance ...

BACKGROUND Leptin, the protein product of the ob gene, has been linked to a faster heart rate in animal and human studies. The interaction between leptin and heart rate in the denervated heart is not known. Therefore, we studied the relationship between plasma leptin levels and heart rate in heart transplant recipients. METHODS AND RESULTS We studied 32 male patients (mean age, 56.5+/-9.3 yea...

OBJECTIVE To determine the association of leptin with insulin resistance, body composition, and lipid parameters in postmenopausal women and men with type 2 diabetes mellitus (T2DM). METHODS This study was conducted in 158 patients (87 postmenopausal women and 71 men) with T2DM, and 99 healthy controls (52 postmenopausal women and 47 men). Type 2 diabetes mellitus patients were selected conse...

We studied growth hormone (GH) and leptin secretion in eight male (age 29.3 +/- 1.2 yr, body mass index 22.2 +/- 0.5 kg/m(2)) and seven female normal subjects (28.0 +/- 0.8 yr, 20.1 +/- 0.7 kg/m(2)) before and after 36 h of fasting. In the fed state, 8-h mean GH and leptin concentrations were higher in females (P < 0.05 and P < 0. 0001, respectively). Fasting increased GH and decreased leptin i...

Obstructive sleep apnoea syndrome (OSAS) is a common disorder in obesity. Leptin, an adipocyte-derived signalling factor, plays an important role in metabolic control. There is growing evidence that leptin regulation is altered in OSAS. Therefore, the aim of this study was to test the hypothesis that effective treatment will influence leptin levels in OSAS patients. Serum leptin levels were det...

BACKGROUND Leptin, a hormone produced primarily by adipose tissue, is known to be present in serum as both monomeric (free) and higher molecular mass (bound) forms, but little is known about the nature of the bound forms or physiological variation in binding capacity. METHODS A new method to quantify the free and bound forms was developed, based on HPLC separation and RIA quantification in ch...

the prevalence of atopic dermatitis (ad) and obesity have been increasing considerably in korean school-children. ad is a chronic pruritic recurrent inflammatory skin disorder. leptin is secreted by adipocytes which has been suggested to be immunologically active; however, their role in ad has not yet been well understood. a total of 227 subjects out of 2,109 elementary school children were def...