Monte Carlo experiments have been used to test the robustness of distribution-free confidence limits for the parameters of the MichaelisMenten equation (Porter & Trager, 1977). When used in conjunction with the modified form of the direct linear plot (Cornish-Bowden & Eisenthal, 1978), they prove to be more robust than least-squares confidence limits. In circumstances where the least-squares as...

This paper provides details on the optimization of phase and amplitude of perturbations for simulated free shear layer flows. The goal of the optimization is to maximize or minimize the rate of growth of the shear layer, based upon firstprinciples physics-based simulations that represent solutions to the fully nonlinear Navier-Stokes equations. These simulations have been obtained using a uniqu...

Derivative free optimization methods have recently gained a lot of attractions for neural learning. The curse of dimensionality for the neural learning problem makes local optimization methods very attractive; however the error surface contains many local minima. Discrete gradient method is a special case of derivative free methods based on bundle methods and has the ability to jump over many l...

We outline the use of a data-free inference procedure for estimation of uncertain model parameters for a chemical model of methane-air ignition. The method involves a nested pair of Markov chains, exploring both the data and parametric spaces, to discover a pooled joint posterior consistent with available information. We describe the highlights of the method, and detail its particular implement...

Again, this can be viewed as a change of variables; on the left-hand side, there are n diagonal free parameters wjj and n(n−1) 2 off-diagonal free parameters wjk, j < k in the matrix W (the remaining offdiagonal parameters are fixed, as W is symmetric); on the right-hand side, there are n free parameters in the matrix Λ and (n − 1) + (n − 2) + . . . + 1 + 0 = n(n−1) 2 free parameters in the mat...

BACKGROUND Abnormalities in thyroid function are frequent in patients with heart failure and are associated with increased mortality. However, the relation between thyroid hormone levels and echocardiographic parameters has not been investigated sufficiently. AIM The aims of this study were to investigate the correlations of thyroid hormone levels with echocardiographic parameters and to eval...

background: leptin is an adipokine that circulates in a free form and bound to a soluble leptin receptor. patients with polycystic ovary syndrome have increased insulin resistance and high incidence of obesity. objective: this study was carried out to evaluate levels of leptin and free leptin in women with polycystic ovarian syndrome (pcos) and note any relationships with insulin resistance and...

In this paper we have studied the effect of free convection on the heat transfer and flow through variable porous medium which is bounded by two vertical parallel porous plates. In this study it is assume that free stream velocity oscillates with time about a constant mean. Periodic temperature is considered in the moving plate. Effect of different parameters on mean flow velocity, Transient ve...