Endocrine disrupting chemicals (EDCs) constitute a major public health concern because they can induce large spectrum of adverse effects by interfering with the hormonal system. Rapid identification potential EDCs using in vitro screenings is therefore critical, particularly for emerging concerns such as replacement flame retardants (FRs). The review aimed at identifying (1) data gaps and resea...

Fibroblast growth factor receptor 1 (Fgfr1) plays pleiotropic roles during embryonic development, but the mechanisms by which this receptor signals in vivo have not previously been elucidated. Biochemical studies have implicated Fgf receptor-specific substrates (Frs2, Frs3) as the principal mediators of Fgfr1 signal transduction to the MAPK and PI3K pathways. To determine the developmental requ...

Identification of patients with a high probability of developing cardiovascular diseases (CVDs) is important for efficient treatment of type 2 diabetes. Although the Framingham risk score (FRS) is considered a useful tool for quantitative assessment of the risk for CVD in the general populations (1,2), the score does not have sufficient power to predict future onset of CVD in type 2 diabetic pa...

CONTEXT Guidelines advise that all adults undergo coronary heart disease (CHD) risk assessment to guide preventive treatment intensity. Although the Framingham Risk Score (FRS) is often recommended for this, it has been suggested that risk assessment may be improved by additional tests such as coronary artery calcium scoring (CACS). OBJECTIVES To determine whether CACS assessment combined wit...

Free relatives as in the English (1) and similar structures in other languages have been described as having definite or universal interpretation (Jacobson 1995, a.o.). They act as DPs and are islands for extraction. We will refer to this type of free relative as definite FRs. In addition to this cross-linguistically common definite FR construction, some languages also have a second free-relati...

In the virtualization based cloud computing environment, multiple computers are allowed to run as virtual machines (VM) in a single physical computer. Efficient scheduling of limited underlying resources has been a key issue. This paper presents a formal method of CPU resources scheduling (FRS). VMs are divided into three resources statuses according to resources requirements and their run info...

RESEARCH DESIGN AND METHODSdA total of 1,123 T2DM participants, ages 34– 86 years, in the Diabetes Heart Study followed up for an average of 7.4 years were separated using baseline computed tomography scans of CAC (0–9, 10–99, 100–299, 300–999, and $1,000). Logistic regression was performed to examine the association between CAC and CVD mortality adjusting for FRS. Areas under the curve (AUC) w...

BACKGROUND In patients with low-intermediate risk, the use of the Framingham Risk Score (FRS) may not allow accurate prediction of the occurrence of coronary events. OBJECTIVE To determine whether non-invasive vascular sonographic assessments add value to the FRS for prediction of coronary events. METHODS Brachial artery flow-mediated dilatation (FMD), carotid intima-media thickness (IMT) a...

INTRODUCTION Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease which has been associated with an increased risk of adverse cardiovascular (CV) outcomes. Adequate stratification of the CV risk is an issue of major importance in patients with HS. To analyze the usefulness of carotid ultrasound (US) assessment for the CV disease risk stratification compared with a tradition...

PURPOSE The association between excess calcium intake and cardiovascular mortality has already been reported. In the present study, we investigated the relation between dietary calcium intake and Framingham Risk Score (FRS) according to serum 25-hydroxyvitamin D [25(OH)D] status. MATERIALS AND METHODS A total of 7809 subjects (3452 males and 4357 female) aged over 40 years were selected for t...