The floor plate is a key organizer that controls the specification of neurons in the central nervous system. Here, we show a new role of the floor plate: segmental pattern formation of the vertebral column. Analysis of a spontaneous medaka mutant, fused centrum (fsc), which exhibits fused centra and the absence of the intervertebral ligaments, revealed that fsc encodes wnt4b, which was expresse...

The emergence of flexible supply chain systems (FSC) has sparked increased interest in real-time planning, scheduling, and logistics--with particular consideration for strategic implications and overall cost control. Important aspects of an FSC include forecasting, production, materials handling, transportation, and distribution center inventory. There exists a variety of software applications ...

Epithelial stem cells divide asymmetrically, such that one daughter replenishes the stem cell pool and the other differentiates. We found that, in the epithelial follicle stem cell (FSC) lineage of the Drosophila ovary, epidermal growth factor receptor (EGFR) signaling functions specifically in the FSCs to promote the unique partially polarized state of the FSC, establish apical-basal polarity ...

Partially observable MDPs provide an elegant framework for sequential decision making. Finite-state controllers (FSCs) are often used to represent policies for infinite-horizon problems as they offer a compact representation, simple-toexecute plans, and adjustable tradeoff between computational complexity and policy size. We develop novel connections between optimizing FSCs for POMDPs and the d...

Snow cover plays a crucial role in surface hydrology and energy balance, especially in the Qinghai-Tibetan Plateau (QTP). This study used 12 years (2000–2011) of ground-observed snow depth at 87 meteorological stations to assess and verify the accuracy of the daily cloud-free snow-cover product from the Moderate Resolution Imaging Spectroradiometer (MODIS) over the QTP. On average, the daily cl...

35 This paper describes research undertaken to establish plausible fuel-speed curves (FSC) for 36 hypothetical advanced powertrain vehicles. These FSC are needed to account for the effects of 37 congestion in long-term transportation scenario analysis considering fuel consumption and 38 emissions. We use the PERE fuel consumption model with real-world driving schedules and a 39 range of vehicle...

PURPOSE To investigate equivalency of results from multivariable regression (MR) and propensity score matching (PSM) models, observational research methods used to mitigate bias stemming from non-randomization (and consequently unbalanced groups at baseline), using, as an example, a large study of chronic obstructive pulmonary disease (COPD) initial maintenance therapy. METHODS Patients were ...

BACKGROUND AND PURPOSE Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for sickle cell anemia (SCA). We report our experience with transplantation in children with the Black African variant of SCA and the effects of transplant on erythroid compartment in bone marrow (BM). PATIENTS AND METHODS Twenty-seven consecutive patients who underwent BM transplan...

Sphericity of erythrocytes can be estimated from analysis of FSC signal distribution in flow cytometry. Previously, Pearson's coefficient of dissymmetry (PCD) and spherical index (SphI) were applied to determine erythrocyte sphericity from the FSC histogram. The aim of the present study is to illustrate the application of kurtosis as an indicator of erythrocyte sphericity in flow cytometry in a...

The humoral mucosal immune response of the kidney involves the transport of secretory IgA (S-IgA) through renal epithelial cells by the polymeric immunoglobulin receptor (pIgR). The pIgR is cleaved and released as free secretory component (FSC) or attached to IgA (S-IgA). We examined the effects of an ischemic model of acute renal failure (ARF) on the expression of pIgR and the secretion of FSC...