Francisella tularensis (Ft) is a category A biothreat agent for which there is no Food and Drug Administration-approved vaccine. Ft can survive in a variety of habitats with a remarkable ability to adapt to changing environmental conditions. Furthermore, Ft expresses distinct sets of antigens (Ags) when inside of macrophages (its in vivo host) as compared to those grown in vitro with Mueller Hi...

BACKGROUND This study explores variables associated with poor prognosis in postoperative p16 positive oropharyngeal squamous cell carcinoma (OPSCC) patients undergoing adjuvant radiotherapy or chemoradiotherapy. Specifically, analysis was done related to timing of feeding tube insertion relative to radiotherapy. METHODS From 1997-2009, of 376 consecutive patients with OPSCC, 220 received adju...

The profile of bioconversion products of istamycin (IS) components by a blocked IS mutant of Streptomyces tenjimariensis that lost IS-productivity suggested a possible biosynthetic pathway of IS similar to that of fortimicin (FT) by Micromonospora olivasterospora. Both organisms are resistant to the antibiotics produced by each other. Based on these similarities, they were examined for their ca...

Arabidopsis FT protein is a component of florigen, which transmits photoperiodic flowering signals from leaf companion cells to the shoot apex. Here, we show that FT specifically binds phosphatidylcholine (PC) in vitro. A transgenic approach to increase PC levels in vivo in the shoot meristem accelerates flowering whereas reduced PC levels delay flowering, demonstrating that PC levels are corre...

FLOWERING LOCUS T (FT) regulates the floral transition in many plant species by integrating environmental seasonal signals and internal cues. Here we show that two interdependent regulatory regions are necessary and sufficient to convey photoperiod responsiveness to FT. While a minimal distance between the regulatory regions is required to fully suppress FT expression under short days, increase...

Detection of subsurface structures by means of gravity method can be used to determine mass distribution and density contrast of rock units. This distribution could be detected by different geophysical methods, especially gravity method. However, gravity techniques have some drawbacks and can't be always successful in distinguishing subsurface structures. Performance of the gravity technique co...

Fast-track (FT) has been shown to enhance post-operative recovery. The aim of this study was to compare the effects of FT and traditional nutrition on post-operative rehabilitation, as well as evaluate the feasibility of applying FT in nutrition management of colorectal surgery. A prospective and randomized controlled trial was performed. This study included 464 patients who underwent colorecta...

Modified Newtonian dynamics, a successful alternative to the cosmic dark matter model, proposes that gravitational field deviates from the Newtonian law when the field strength g is weaker than a critical value g0. We will show that the dynamics of MOND can be derived from an induced gravity model. New dynamics is shown to be compatible with the spatial deformation of scalar fields coupled to t...

The Langley 8-Foot High-Temperature Tunnel (8-ft HTT) is used to test components of hypersonic vehicles for aerothermal loads de nition and structural component veri cation. The test medium of the 8-ft HTT is obtained by burning a mixture of methane-air under high pressure; the combustion products are expanded through an axisymmetric conical-contoured nozzle to simulate atmospheric ight at Mach...