Bacteria are often isolated in stable chronic obstructive pulmonary disease (COPD). Whether fungi are also commonly present and associated with clinical and pathological features of disease is uncertain. We investigated the frequency of filamentous fungal culture and IgE sensitisation to Aspergillus fumigatus and the relationship to clinical outcomes in COPD subjects. COPD subjects were recruit...

Hypersensitivity pneumonitis (HP) (J67) is the most common interstitial lung disease in children and adolescents. The immunologically determined, it can be a when exposed to various factors that cause harmful effects on environment. significant are thermophilic actinomycetes, antigens of animal fungal origin. Currently, cases “two infection” have been identified, genetic predisposition has iden...

BACKGROUND : Fungal allergens are ubiquitous; however, little progress has been made understanding fungal allergenic material removal from indoor environments. PURPOSE : We investigated removal of environmental allergenic material derived from Alternaria and Cladosporium using sodium hypochlorite in vivo and in vitro. METHODS : Freeze dried allergen extract from Alternaria alternata and Cla...

OBJECTIVES Moulds are frequently found in the indoor environment of residential houses. An association between domestic mould contamination and respiratory symptoms has been reported, but mould exposure as a risk factor for allergy to moulds is not well documented. The aim of the study was to evaluate the prevalence and associated factors of allergic hypersensitivity to moulds. MATERIALS AND ...

We herein report a case of sinobronchial allergic mycosis (SAM) caused by basidiomycetous (BM) fungi (probably Phanerochaete velutina). The patient with bronchial asthma that accompanied allergic fungal sinusitis (AFS) fulfilled all 6 criteria for diagnosing SAM. In this case, the BM fungus may act as an allergen, reacting continually in both the upper and lower respiratory tract. The antifunga...

BACKGROUND Aspergillus fumigatus (Af) sometimes colonizes and persists within the respiratory tree in some patients with asthma. To date, the precise reasons why the clearance of Af is impaired in patients with asthma remain unknown. OBJECTIVE To characterize the effects of allergic airway inflammation on clearance of Af. METHODS Control and Dermatophagoides farinae (Df) allergen-sensitized...

Fungal growth in damp or water-damaged buildings worldwide is an increasing problem, which has adverse effects on both the occupants and the buildings. Air sampling alone in moldy buildings does not reveal the full diversity of fungal species growing on building materials. One aim of this study was to estimate the qualitative and quantitative diversity of fungi growing on damp or water-damaged ...

background: the cultivation of saffron is expanding through the southeast of iran, and allergy to saffron pollen occurs in workers involved in processing this plant. we aimed to clone, sequence and express a major allergen involved in saffron pollen allergy, and to compare the recombinant with the natural allergen. methods: the n-terminal amino acid sequence of cro s 1, an allergen from saffron...

pollen from mesquite (prosopis juliflora) is one of the important causes of immediate hypersensitivity reactions in the arid and semi-arid regions of the world. the aim of present study is to produce and purify the recombinant form of allergenic ole e 1-like protein from the pollen of this allergenic tree. immunological and cross-inhibition assays were performed for the evaluation of ige-bindin...

Molds are often found in patients with pre-existing asthma, when they can be the cause of worsening asthma and even death. However, also represent a risk factor for development previously healthy person. The most allergenic molds causing respiratory diseases are: Aspergillus, Alternaria, Penicillium Cladosporium an emphasis on Aspergillus asthma. In order to inhaled their spores must ≤5 µm size...