Sensitization to fungi and long term or uncontrolled fungal infection are associated with poor control of asthma, the likelihood of more severe disease and complications such as bronchiectasis and chronic pulmonary aspergillosis. Modelling suggests that >6.5 million people have severe asthma with fungal sensitizations (SAFS), up to 50% of adult asthmatics attending secondary care have fungal se...

PURPOSE Fungi have been known to be important aeroallergens for hundreds of years. Most studies have focused on total fungal concentration; however, the concentration of specific allergenic fungi may be more important on an individual basis. METHODS Ten fungal allergic patients and 2 non-fungal allergic patients were enrolled. The patients with a decrease in physician or patient global assess...

Innate and cell-mediated immunity are considered as the principal defence lines against fungal infections in humans. Most opportunistic mycoses occur in individuals with defective innate and/or adaptive cellular immunity. The morbidity and mortality rates associated with infections caused by fungal pathogens are high, and prevention, diagnosis and treatment of these infections remain quite diff...

BACKGROUND The frequency and concentration of many airborne fungal spores associated with respiratory allergy symptoms are influenced by geographical and climatic characteristics. OBJECTIVE The aim of this work was to monitor the distribution of 11 potentially allergenic fungal spore types in 2 regions with different urbanization levels in Northern Portugal: Porto (urban area) and Amares (rur...

BACKGROUND AND PURPOSE Allergy is an undesired immune response to non-pathogenic agents. However, some opportunistic microorganisms such as fungi can also cause allergy. Among those fungi, hyphae form of Aspergillus strains including A. fumigatus, A. flavus, and A. niger could be mentioned. In this study, we aimed to separate allergic proteins from Aspergillus strains and determine their identi...

Chowdhary et al. reported that Schizophyllum commune is the predominant causative antigen of allergic bronchopulmonary mycosis (ABPM) (1). In a series of studies regarding Schizophyllum allergy in respiratory disease, they successfully demonstrated the in vitro profiles of the antifungal susceptibility of S. commune (2). Those studies raise questions regarding how the antifungal susceptibility ...