A significant increase in breast cancer (BC) rates has been observed among pre-menopausal woman. Considering the higher number of patients (pts) who have not completed their family planning and impact age on fertility, fertility preservation (FP) is proving to be a major challenge. Gemme Dormienti Onlus (GD) an italian association that helps pts by promoting valid model FP counselling. Our aim ...

objective(s):brucellosis, especially caused by brucella melitensis, remains one of the most common zoonotic diseases worldwide with more than 500,000 human cases reported annually. the commonly used live attenuated vaccine in ovine brucellosis prophylaxis is b. melitensis rev1. but due to different problems caused by the administration of this vaccine, a protective subunit vaccine against b. me...

The main aim of this study was to obtain the Crimean-Congo hemorrhagic fever virus (CCHFV) glycoprotein, through either stable transgenic plants or using a transient expression system, and determine the yield, quality and finally the immunogenicity of the plant-made CCHFV glycoprotein in a mouse model. We designed and synthesized a codon-optimized G1/G2 gene from the G1 and G2 parts of the CCHF...

background: dermatophagoides farinae and dermatophagoides pteronyssinus are house dust mites (hdm) that they cause severe asthma and allergic symptoms. tropomyosin protein plays an important role in mentioned immune and allergic reactions to hdms. here, tropomyosin protein from dermatophagoides spp. was comprehensively screened in silico for its allergenicity, antigenicity and similarity/conser...

Iota toxin is produced by Clostridium perfringens type E. This toxin causes antibiotic-associated enterotoxemia in lambs and calves. Iota toxin is a binary toxin that has two components including Ia (the enzyme component) and Ib (the binding component). Ib binds to the surface receptor of target cells and translocate Ia into the cytosol of cells. The aim of this study was to clone toxigenic epi...

Brucellosis, produced by Brucella species, is a disease that causes severe economic losses for livestock farms worldwide Due to serious economic and medical consequences of this disease, many efforts have been made to prevent the infection through the use of recombinant vaccines based on Brucella outer membrane protein (OMP) antigens. In the present study, a wide range of on-line prediction sof...

for two given graphs g1 and g2, the ramseynumber r(g1,g2) is the smallest integer n such that for anygraph g of order n, either $g$ contains g1 or the complementof g contains g2. let tn denote a tree of order n andwm a wheel of order m+1. to the best of our knowledge, only r(tn,wm) with small wheels are known.in this paper, we show that r(tn,wm)=3n-2 for odd m with n>756m^{10}.

Summary To fully decipher the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein, it is essential to assess which part highly immunogenic in a systematic way. We generate linear epitope landscape protein by analyzing serum immunoglobulin G (IgG) response 1,051 disease 2019 (COVID-19) patients with peptide microarray. reveal two regions rich epi...

supramolecule self assembly polyamidoamine (pamam) dendrimer refers to the chemical systems made up of a discrete number of assembled molecular subunits or components. these strategies involve the covalent assembly of hierarchical components reactive monomers, branch cells or dendrons around atomic or molecular cores according to divergent/convergent dendritic branching principles, systematic f...