Human Na(+)-D-glucose cotransporter (hSGLT) inhibitors constitute the newest class of diabetes drugs, blocking up to 50% of renal glucose reabsorption in vivo. These drugs have potential for widespread use in the diabetes epidemic, but how they work at a molecular level is poorly understood. Here, we use electrophysiological methods to assess how they block Na(+)-D-glucose cotransporter SGLT1 a...

Wish you and your family a Happy New Year! This issue of Asia Pacific allergy (AP Allergy) is very meaningful because it has been successfully published for full four years (16 issues so far) since the launching ceremony on November 6, 2010 and its inaugural issue release on April 30, 2011. Thank you very much for your support. AP Allergy has been recognized as an important journal in the field...

The most common wood species in Sweden, and one of the most important renewable raw materials in Northern Europe, is Norway spruce (Picea abies). Today, it is utilized mainly for sawed timber and the production of pulp and paper. A modern kraft pulp mill that produces bleached pulp has a material efficiency of about 40-45%, and the final product contains mainly cellulose. The other components o...

Tubulointerstitial injury is central to the progression of end-stage renal disease. Recent studies have revealed that one of the most investigated uremic toxins, indoxyl sulfate (IS), caused tubulointerstitial injury through oxidative stress and endoplasmic reticulum (ER) stress. Because indole, the precursor of IS, is synthesized from dietary tryptophan by the gut microbiota, we hypothesized t...

Volume 61, no. 11, p. 4022, column 2, line 10: "K(inf2)HSO(inf4)" and "KH(inf2)SO(inf4)" should read "K(inf2)HPO(inf4)" and "KH(inf2)PO(inf4)," respectively. Line 13: "K(inf2)HSO(inf4)" should read "K(inf2)HPO(inf4)." Line 14: "KH(inf2)SO(inf4)" and "0.2 g of CaCO(inf3)" should read "KH(inf2)PO(inf4)" and "1 g of CaCO(inf3)," respectively. [This corrects the article on p. 4022 in vol. 61.].

T2-weighted coronal images of hind limb region with a subcutaneous tumor (yellow circle); pre(A, E) and 3 h post-contrast injection (B, F). Fluorescence images (C, G) and Perl’s staining (D, H) of tumor tissue. Injected contrast agent: control NE (A-D) or RGD-NE (E-H). Figure 1. Negative staining TEM (A) and schematic representation (B) of RGD-NE. RGD-Functionalized Superparamagnetic Nanoemulsi...