The healing potential of scaffolds for tissue engineering can be enhanced by combining them with genes to produce gene-activated matrices (GAMs) for tissue regeneration. We examined the potential of using polyethyleneimine (PEI) as a vector for transfection of mesenchymal stem cells (MSCs) in monolayer culture and in 3D collagen-based GAMs. PEI-pDNA polyplexes were fabricated at a range of N/P ...

in this paper, a robust model presented is developed for hub covering flow problem in which hubs have capacity. this problem has two objective functions converting to a single-objective problem by using weighting method. firstly, the problem will be formulated in a certain case. then, by considering the demand as a non-random variable, it will be modeled by robust optimization. finally, by usin...

With increasing importance placed on standard quality assurance methodologies by large companies and government organizations, many software companies have implemented rigorous quality assurance (QA) processes to ensure that these standards are met. The satisfaction of these quality checks ensures that the software has achieved a certain level of compliance to standards and thereby gives the co...

It is planned to use external magnetic perturbations at acoustic frequencies at the DIII-D tokamak to attempt to drive geodesic acoustic modes (GAM) to modify the turbulent transport. We show that this might not only be possible--despite the well-known electrostatic nature of the GAMs--but might be a viable and efficient method to generate GAMs in magnetically confined plasmas, by developing an...

This document describes some issues with respect to solving systems of linear equations Ax = b using GAMS.

As a substantial part of the brain tumor microenvironment (TME), glioma-associated microglia/macrophages (GAMs) have an emerging role in tumor progression and in controlling anti-tumor immune responses. We review challenges and improvements of cell models and highlight the contribution of this highly plastic cell population to an immunosuppressive TME, besides their well-known functional role r...

We discuss a tank design problem for a multi product plant, in which the optimal cycle time and the optimal campaign size are unknown. A mixedinteger nonlinear programming (MINLP) formulation is presented, where non-convexities are due to the tank investment cost, storage cost, campaign setup cost and variable production rates. The objective of the optimization model is to minimize the sum of t...

Single-site recreation demand and dichotomous choice contingent valuation analyses are typically conducted by implementing models containing strong parametric assumptions, which are rarely underpinned by theoretical arguments. This work illustrates how these assumptions can be relaxed and the estimation conducted semiparametrically by using generalized additive models (GAMs). This approach dire...

Ozone observations by the Gas and Aerosol Measurement Sensor during SOLVE II M. C. Pitts, L. W. Thomason, J. M. Zawodny, B. N. Wenny, J. M. Livingston, P. B. Russell, J.-H. Yee, W. H. Swartz, and R. E. Shetter NASA Langley Research Center, Hampton, Virginia, USA Science Applications International Corporation, Hampton, Virginia, USA SRI International, Menlo Park, California, USA NASA Ames Resear...