Introduction Ganoderma lucidum, an oriental fungus has a long history of use for promoting health and longevity in China, Japan, and other Asian countries. In China, G. lucidum is called lingzhi, whereas in Japan the name for the Ganodermataceae family is reishi. Ganoderma has a unique double walled basidiospore with a shining skin. Some of the active compounds identified in the cell wall of th...

We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). By spectroscopy, we compared the structures of these compounds with known related compounds in this group. All of the isolated compounds were assayed for their effect against the human breast carcinoma cell line MDA-MB-231 and hepatocellular carcinoma cell line H...

Five new highly oxygenated lanostane-type triterpenoids [ganoderic acid GS-1 (1), ganoderic acid GS-2 (2), ganoderic acid GS-3 (3), 20(21)-dehydrolucidenic acid N (4) and 20-hydroxylucidenic acid A (5)] were isolated from the fruiting body of Ganoderma sinense, together with known compounds including 6 triterpenoids and 3 sterols. The structures of the new triterpenoids determined by spectrosco...

Bioassay-guided fractionation of methanol extract of Ganoderma lucidum gave a pure cholesterol esterase inhibitor. On the basis of spectroscopic analysis and comparison with data from the literature, its structure was identified as 5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol (compound I). Compound (I) inhibited cholesterol esterase with an IC50 value of 42 micronM. A Lineweaver-Burk plot r...

backgrounds and objectives : ganoderic acids are the most valuable secondary metabolites in ganoderma lucidum traditional medicinal mushrooms, which have shown antitumor properties in many studies. however, application of ganoderic acids is limited due to low yield production. recently, it was shown that static liquid culture could be a proven technology for producing ganoderic acids in ganoder...

Ganoderma resinaceum is usually used as ethnomedicine for immune-regulation, hyperglycemia, and liver disease. To date, only a few chemical constituents have been reported from G. resinaceum. In this study, fifteen nortriterpenoids including six new nortriterpenoids (1-6) and nine known analogs (7-15), were separated and purified from the fruiting bodies of G. resinaceum. New compounds were ide...

Statistical optimization of culture conditions for enhanced mycelial biomass production using Ganoderma lucidumPooja Shah, Hasmukh Modi

Ganoderma resinaceum tolerated sodium chloride salt stress within a range of 0 mM till 300 mM. It responded to salt stress with fluctuation in proline formation at different NaCl concentrations. However,the mycelial dry weight,total protein contents and exopolysaccharides did not changed considerably. Increasing sodium chloride concentration led to morphological alteration in fungal mycelia wit...