Gastric ulcers have been considered as a major problem worldwide. This study investigated the protective synergistic effect of novel nutrient formulation for protection and treatment indomethacin-induced gastric ulcer in rat model. 24, 8 w old male rats with body weight between 220 240 g, were divided into four groups used this study. Group 1 consists healthy controls group 2 ulcerative animals...

The association between corticosteroid treatment and gastric ulcer healing is controversial. The effects of corticosteroids on experimental ulcer healing in the rat were studied and the effect of coadministration of a prostaglandin E1 analogue was determined. Forty male adult rats were divided into five groups and pretreated for 10 days as follows: (a) control, (b) prednisolone (10 mg/kg), (c) ...

Sixteen cases are described of gastric ulcer in patients receiving anti-arthritic drugs. Half of the ulcers were in the antrum or on the greater curve. Ten patients were under treatment with indomethacin and/or prednisone, seven of them receiving both drugs. The ulcers healed readily when the drugs were withdrawn, and in the case of prednisone a continued daily dose of 10 Ing or less did not pr...

BACKGROUND Melissa officinalis (MO) has potent antioxidant activity. Recent research has demonstrated the anti-ulcer properties of some medicinal plants through their antioxidant properties. OBJECTIVES The aim of this study was to evaluate the effects of methanolic extracts of MO on experimental gastric ulcers in rats. MATERIALS AND METHODS Male Wistar rats (200 - 250 g) were starved for 24...

In this study, it was aimed to investigate the gastroprotective and anti-inflammatory effects of extract (TO) obtain from leaves Taraxacum officinale, which is used in treatment many diseases including gastric ulcers traditional medicine, an indomethacin-induced ulcer model. Forty rats, 10 animals each group, were divided into four groups (Control (C), TO + Indomethacin (TO+IND), (IND) Omeprazo...

The objective of the present study was to investigate the antiulcer activity of methanol extract of Oxalis corniculata (whole plant) using pylorus ligation and indomethacin-induced gastric ulceration in Wistar rats. The extract was preliminary evaluated for acute oral toxicity test using Organisation for Economic Co-operation and Development guidelines 423. Further, it was studied for antiulcer...

Objective: Nelumbo nucifera Gaertn. (Nymphaeceae) is a well known aquatic herb which has been extensively used traditionally for the treatment of different diseases. Therefore present study was designed to evaluate the anti-ulcer activity of methanolic extract of Nelumbo nucifera Gaertn. (Nymphaeceae) stalks. Methods: Anti-ulcer activity of methanolic extract of Nelumbo nucifera (100 mg/kg and ...

A group of novel nitric oxide (NO) donating chalcone derivatives was prepared by binding various amino chalcones with different NO donating moieties including; nitrate ester, oximes and furoxans. Most of the prepared compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared with indomethacin. The prepared compounds exhibited more protection ...

Study was aimed to evaluate the possible antisecretory and antiulcer activity of crude bark extract of Acacia catechu and its action against indomethacin an non steroidal anti inflammatory drug (NSAID) plus pyloric ligation induced gastric ulcers in rats. Administration of crude extract of Acacia catechu (400mg/kg/day p.o.) significantly reduced ulcer index when compared with indomethacin induc...