BACKGROUND Cystatin C is a low molecular weight protein produced by all nucleated human cells, with a stable production rate. Its levels are not influenced by inflammation, infections, hepatic or renal diseases, or by dietary or constitutional factors. We compared serum cystatin C and serum creatinine based predicting equations to estimate glomerular filteration rate (GFR) in type 2 diabetes me...

background glomerular filtration rate (gfr) is widely estimated by serum creatinine based equations such as cockcroft-gault (cg) standardized for body surface, and an abbreviated formula derived from mdrd (modification of diet in renal disease) study. however, some studies suggested that creatinine based estimation of gfr formula can be replaced by cystatin c based formula. objectives the aim o...

UNLABELLED We evaluated in elderly subjects (a) the ability of GFR formulas to discriminate chronic kidney disease (CKD), (b) the correlation between renal morphology and function, and (c) the usefulness of combined r-US and GFR formulas to detect CKD. A total of 72 patients were enrolled (mean age 80±7 years, male sex 44%, serum creatinine 0.98±0.42 mg/dL, and CKD 57%). Cockcroft-Gault showed ...

BACKGROUND AND PURPOSE The objective of this study was to determine the relationship between chronic kidney disease (CKD), race-ethnicity, and vascular outcomes. METHODS A prospective, multiracial cohort of 3298 stroke-free subjects with 6.5 years of mean follow-up time for vascular outcomes (stroke, myocardial infarction, vascular death) was used. Kidney function was estimated using serum cr...

Background: Ethnic variabilities make reliability of formula equations for assessing glomerular filtration rate (GFR) doubtful in many populations. We compared Cockroft-Gault (CG), modification diet renal disease (MDRD), and chronic kidney diseases epidemiology collaboration (CKD-EPI) adult Nigerian CKD subjects.
 Methodology: measured 24-hour-urinary creatinine clearance 311 patients with...

BACKGROUND AND OBJECTIVES We compared the estimations of Cockcroft-Gault, Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations to a gold standard GFR measurement using (125)I-iothalamate, within strata of GFR, gender, age, body weight, and body mass index (BMI). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS For people who prev...

BACKGROUND Seminoma stage I is the most frequent testis cancer and single-dose carboplatin (AUC7) is an effective and widely used adjuvant treatment. Underdosing of carboplatin by 10% has been shown to almost double the rate of relapse and hence correct dosing based on accurate GFR measurement is crucial. The gold standard of GFR measurement with a radiolabelled isotope is expensive and not rea...

BACKGROUND Detection of renal dysfunction is important in critically ill patients, and in daily practice, serum creatinine is used most often. Other tools allowing the evaluation of renal function are the Cockcroft-Gault and MDRD (Modification of Diet in Renal Disease) equations. These parameters may, however, not be optimal for critically ill patients. The present study evaluated the value of ...