Gel dosage forms are successfully used as drug delivery systems to control drug release and protect the medicaments from a hostile environment. The main objective is to formulate and evaluate in situ oral topical gels of clotrimazole based on the concept of pH triggered and ion activated systems. The system utilizes polymers that exhibit sol-to-gel phase transition due to change in specific phy...

By programmable annealing, photothermal gold nanoclusters were integrated into filamentous aggregates of gellan gum to obtain a photofunctional fibrous substrate that enhanced cell adhesion and permitted light-triggered growth promotion.

Gellan gum is a biocompatible and easily accessible polysaccharide with excellent properties to produce microparticles as drug delivery systems. However, the production methods often fail in reproducibility, compromising translational potential of such In this work, gellan gum-based was optimized using coaxial air flow method, an inexpensive reproducible method. A design experiments used identi...

Gellan Gum (GG) has been recently proposed for tissue engineering applications. GG hydrogels are produced by physical crosslinking methods induced by temperature variation or by the presence of divalent cations. However, physical crosslinking methods may yield hydrogels that become weaker in physiological conditions due to the exchange of divalent cations by monovalent ones. Hence, this work pr...

Objective: The objective of the current investigation was to design aceclofenac encapsulated microbeads using gellan gum and linseed blends following ionotropic gelation by trivalent Al3+-ions as cross-linking agent. Methods: Various formulation parameters like polymer-polymer blend (gellan gum), proportion concentration aluminium chloride (i.e., cross-linker) were considered for preparation di...