BACKGROUND AND PURPOSE Contrast leakage results in underestimation of the CBV of brain tumors. Our aim was to compare the diagnostic performance of DSC perfusion MR imaging without and with mathematic contrast-leakage correction in differentiating PCNSLs and glioblastomas. MATERIALS AND METHODS Perfusion parameters-CBV, corrected CBV, and leakage coefficient-were measured in enhancing tumor p...

Introduction. glioblastomas multiforme (grade Iv gliomas) are common and the most aggressive primary tumors of brain with very unfavorable prognosis. In all previously published papers on epileptiform activity in glioblastomas, not enough information encephalogram results is presented. Aim. To study features patients development a plan for further these patients. Materials methods. An analysis ...

The neurotrophic hepatocyte growth factor attenuates CD8+ cytotoxic T-lymphocyte activity BENKHOUCHA, Mahdia, et al. BENKHOUCHA, Mahdia, et al. The neurotrophic hepatocyte growth factor attenuates CD8+ cytotoxic T-lymphocyte activity. CD40/CD40L expression correlates with the survival of patients with glioblastomas and an augmentation in CD40 signaling enhances the efficacy of vaccinations and ...

Introduction Glioblastomas, brain metastases and primary cerebral lymphomas are common brain malignancies with similar enhancement pattern on magnetic resonance (MR) imaging. Despite some characteristic MR imaging findings, it is often difficult or even impossible to differentiate these neoplasms. Accurate preoperative diagnosis is crucial as the management and prognosis of these tumors are sub...

Bilateral thalamic tumors are rare. Pediatric bilateral thalamic glioblastomas are even rarer, only five cases reported in the English literature till date. The clinical presentation, natural history, and prognosis of pediatric thalamic tumors are still relatively obscure. In this article, we report an 8-year-old patient with large bilateral thalamic glioblastomas and briefly discuss its clinic...

The present study proposed a computer-aided diagnosis system based on radiomic features extracted through magnetic resonance imaging to determine the isocitrate dehydrogenase status in glioblastomas. Magnetic resonance imaging data were obtained from 32 patients with wild-typeisocitrate dehydrogenase and 7 patients with mutant isocitrate dehydrogenase in glioblastomas. Radiomic features, namely...

but were increased around areas of necrosis and around blood vessels. No relationship between tumour cell proliferation and necrosis was detected. Conclusions: Tumour cell proliferation is concentrated around blood vessels in glioblastomas. Blood vessel proliferation, but not tumour cell proliferation, is related to areas of necrosis and the presence of macrophages in glioblastomas. Targeting o...