ABSTRACTTuberculosis is an infectious disease which occurs widely in the world and becomes one of the top 10 causes of death worldwide. Mutations of the RpoB gene cause the resistance of Mycobacterium tuberculosis to rifampicin that contributes to the occurrence of MDR-TB. This study aimed to determine the pattern of rpoB gene polymorphisms in the MDR M. tuberculosis in Semarang, Indonesia. Mos...

Interleukin 8 (IL8) is an important chemokine that elicits host immune response against tuberculosis (TB). However, whether there is an association between IL8 gene polymorphism and TB susceptibility in the Chinese population is unknown. IL8 gene was amplified and sequenced to search for nucleotide polymorphisms among the Chinese population. Four single nucleotide polymorphisms (SNPs) were iden...

In vitro, animal model and anecdotal clinical evidence suggests that tuberculosis (TB) is not a monomorphic disease, that host response to TB protean with multiple distinct molecular pathways pathologies (endotypes). We used unbiased clustering identify separate endotypes distinctive gene expression patterns different outcomes. A discovery cohort included 443 patients 527 asymptomatic controls ...

BACKGROUND: Streptomyces sp. from Indonesian soil have not been explored and isolated to find new strains as a source of antibiotics for the treatment tuberculosis (TB) disease. AIM: In this study, effect spp. Lapindo mud in Sidoarjo, Indonesia be observed, out whether has anti-TB activity. METHODS: The primers Strep F; 5-AGAGTTTGAT CCTGKGTCAG-3 R; 5-AAGGGAG GTGATCCAKKGKGA-3 were used polymeras...

This panel presented data on host genes that influence susceptibility to or manifestations of four infectious diseases: Puumala hantavirus infection, tuberculosis (TB), Lyme disease, and AIDS. Gus Birkhead, Council of State and Territorial Epidemiologists, introduced the session, highlighting its timeliness in relation to the rapidly emerging body of data on our 100,000 human genes that stems f...

Background: Tuberculosis (TB) is one of the most common and deadly infectious diseases in humans. Due to widespread poverty, inequity, conflict, suboptimal health services many countries, impact HIV/AIDS pandemic, TB/HIV co-infected patients frequently test negative for TB with direct microscopy, posing diagnostic challenges. Traditional HIV-associated diagnosis complex, expensive, time-consumi...

This panel presented data on host genes that influence susceptibility to or manifestations of four infectious diseases: Puumala hantavirus infection, tuberculosis (TB), Lyme disease, and AIDS. Gus Birkhead, Council of State and Territorial Epidemiologists, introduced the session, highlighting its timeliness in relation to the rapidly emerging body of data on our 100,000 human genes that stems f...

Traditional treatments for spinal tuberculosis (TB) involve chemotherapy and surgery. In the present study, it has been identified that chemotherapy lasting <6 months [ultra-short course chemotherapy (UCCT)], rather than the 6-18 months of the traditional regimen, is effective in sustaining TB clearance following complete surgical debridement. This current study aims to compare the changes in p...

BACKGROUND The objectives of the study were to compare the performance of line probe assay (GenoType MTBDRplus) with solid culture method for an early diagnosis of multidrug resistant tuberculosis (MDR-TB), and to study the mutation patterns associated with rpoB, katG and inhA genes at a tertiary care centre in north India. METHODS In this cross-sectional study, 269 previously treated sputum-...

BACKGROUND Vitamin D modulates the inflammatory and immune response to tuberculosis (TB) and also mediates the induction of the antimicrobial peptide cathelicidin. Deficiency of 25-hydroxyvitamin D and single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene may increase the risk of TB disease and decrease culture conversion rates in drug susceptible TB. Whether these VDR SNP...