The fitness of an individual bacterial cell is highly dependent upon the temporal tuning gene expression levels when subjected to different environmental cues. Kinetic regulation transcription initiation a key step in modulating transcribed genes promote survival.

Abstract Dysregulation of gene expression plays an important role in cancer development. Identifying transcriptional regulators, including transcription factors and chromatin that drive the oncogenic program is a critical task research. Genomic profiles active regulators from primary samples are limited public domain. Here we present BART Cancer (bartcancer.org), interactive web resource databa...

Transcription is an essential process in biology whereby gene-specific transcription factors target sites on DNA to recruit the basal machinery that will produce messenger RNA (mRNA). It a highly regulated multi-step involves many proteins and protein complexes. factors, mark genes for activation, other transcriptional regulators are enriched low-complexity disordered regions, which strongly li...

Patient outcomes in T-cell acute lymphoblastic leukemia and lymphoma (T-ALL/LBL) can be difficult to predict. Simonin et al report deletions mutations the gene encoding transcription factor IKAROS among 1260 children adults with immature T-ALL/LBL, defining its frequency and, importantly, association poor outcome multivariate models. Pathogenic alterations IKZF1 now added minimal residual disea...

The pituitary-specific transcription factor (PIT1) gene is responsible for pituitary development and hormone secreting gene expression in mammals. PIT-1 is studied as a candidate genetic marker for growth, carcass and also for milk yield traits. In dairy farm animals, the principal goal of the selection is the improvement of milk yield and composition. The genes of milk proteins and hormones ar...

Plants have an extraordinary diversity of transcription machineries, including five nuclear DNA-dependent RNA polymerases. Four these enzymes are dedicated to the production long noncoding RNAs (lncRNAs), which ribonucleic acids with functions independent their protein-coding potential. lncRNAs display a broad range lengths and structures, but they distinct from small guides interference (RNAi)...

Macrophages play a critical role in lung injury and repair processes. Their functions can be broadly classified into two polarized phenotypes. The M1 macrophages promote inflammation defense against pathogens, while the M2 are involved tissue resolution of inflammation. Gene manipulation techniques used to modulate macrophage polarization during injury. 1. Transcription factors: factors protein...

lymphomas are solid tumors of immune system and non-hodgkin lymphomas (nhl) is the most prevalent lymphomas; with wide ranges of histological and clinical features, it is so difficult to identify them. herein, various bioinformatics tools (such as gene differential expressions, epigenetics and protein analysis) employed to find new treatment approach for nhl based on gene expression variation b...

abiotic stress such as cold and drought has adverse effects on plants growth and development. abiotic stress resistance is one of the most important goals in plant breeding. this goal can be achieved through transcription factor gene transfer to plants. recent studies show many successes in improving abiotic stress resistance by use of transcription factor gene transfer. the objective of the re...