نتایج جستجو برای: genetic vaccine
تعداد نتایج: 717612 فیلتر نتایج به سال:
The first candidate rotavirus vaccine was a live attenuated oral vaccine made by the classical empirical method of serial passage of virus in tissue culture cells. Current tetravalent vaccine candidates that are in the final stages of efficacy testing in the United States were made by genetic reassortment. This article briefly highlights how advances in the basic understanding of the molecular ...
BACKGROUND Influenza vaccine composition is reevaluated each year due to the frequency and accumulation of genetic changes that influenza viruses undergo. The beginning of the 2016-2017 influenza surveillance period in Israel has been marked by the dominance of influenza A(H3N2). OBJECTIVES To evaluate the type, subtype, genetic evolution and amino acid substitutions of influenza A(H3N2) viru...
Although Plasmodium vivax is a leading cause of malaria around the world, only a handful of vivax antigens are being studied for vaccine development. Here, we investigated genetic signatures of selection and geospatial genetic diversity of two leading vivax vaccine antigens--Plasmodium vivax merozoite surface protein 1 (pvmsp-1) and Plasmodium vivax circumsporozoite protein (pvcsp). Using scala...
Background: Several of the intended P. falciparum vaccine candidate antigens are highly polymorphic and could render a vaccine ineffective if their antigenic sites were not represented in the vaccine. This study aimed to characterize genetic diversity of vaccine candidate antigens merozoite surface protein-3 (MSP-3), apical membrane antigen-1 (AMA-1) and erythrocyte binding antigen (EBA-175) in...
The role of immunity to intracellular Ags in resistance to infection by Yersinia is not well established. The enteropathogenic bacteria Yersinia pseudotuberculosis and Yersinia enterocolitica actively translocate Ags to the cytosol of eukaryotic cells. Whereas Yersinia pestis does not always express the requisite cellular adhesins, results have varied as to whether similar cytosolic translocati...
To combat the high burden of rotavirus gastroenteritis, multiple African countries have introduced rotavirus vaccines into their childhood immunization programs. Malawi incorporated a G1P[8] rotavirus vaccine (Rotarix) into its immunization schedule in 2012. Utilizing a surveillance platform of hospitalized rotavirus gastroenteritis cases, we examined the phylodynamics of G1P[8] rotavirus strai...
The Australian Paediatric Surveillance Unit (APSU) conducts national active surveillance of rare diseases of childhood, including infectious and vaccine preventable diseases, genetic disorders, childhood injuries and mental health conditions. The study of communicable and vaccine-preventable diseases is supported by the Australian Government Department of Health and Ageing through its communica...
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