OBJECTIVES Thyroid antibody positivity during pregnancy has been associated with adverse outcomes including miscarriage and preterm delivery. The aim of the study is to evaluate the obstetric outcome in pregnant women with recurrent miscarriage and their response to levothyroxine (l-T4) therapy. STUDY DESIGN AND METHODS All pregnant and non-pregnant women between 21 and 35 years of age with a...

BACKGROUND The link between type 1 diabetes and thyroid autoimmunity is well described. The same cannot be said for type 2 diabetes where results have been mixed so far. We investigated the prevalence and determinants of thyroid autoimmunity among Ghanaian type 2 diabetes patients. METHODS This was a case-control study involving 302 type 2 diabetes patients and 310 non - diabetic controls age...

BACKGROUND Gestational thyroid dysfunction is common and associated with maternal and child morbidity and mortality. During pregnancy, profound changes in thyroid physiology occur, resulting in different thyroid-stimulating hormone (TSH) and free thyroxine (FT4) reference intervals compared to the nonpregnant state. Therefore, international guidelines recommend calculating trimester- and assay-...

In this issue Kazerooni and colleagues have authored an interesting article entitled “Correlation between thrombophilia and recurrent pregnancy loss in patients with polycystic ovary syndrome (PCOS): A comparative study”. Based on the absence or presence of recurrent pregnancy loss (RPL) and polycystic ovary syndrome (PCOS), the authors have tried to determine the association of thrombophilia a...

Background The wide range of adverse outcomes of thyroid dysfunction and autoimmunity on pregnancy and the offspring (1-5) makes early and reliable detection of paramount importance; therefore, screening for thyroid dysfunction is recommended in pregnancy. However, it is not yet clear whether screening should be clinically oriented or universal. Targeted case finding for the presence of antithy...

OBJECTIVE To assess the relation between thyroid parameters and an episode of major depression at different trimesters during pregnancy, taking into account possible confounders. DESIGN Prospective follow-up of 1017 pregnant women from the general population with assessment of thyroid parameters and depression using syndromal diagnosis interviews at 12, 24, and 36 weeks' gestation. MAIN OUT...

Hashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disorder. Intrathyroidal lymphocytic infiltration is followed by a gradual destruction of the thyroid gland which may lead to subclinical or overt hypothyroidism. Biochemical markers of the disease are thyroid peroxidase and/or thyroglobulin autoantibodies in the serum which are present with a higher prevalence in females tha...

Thyroid nodules are a very frequent pathology among common population. Despite the vast majority of them are of benign origin, the incidence of thyroid cancer is currently rather rising. Although there are several risk factors of thyroid cancer and several clinical, ultrasound, biochemical and molecular diagnostic markers, the exact mechanisms of thyroid oncogenesis and the linkage between thyr...