Advancement in the medical sectors to treat regular diseases are increasing day-by-day. Yet, there is a considerable growth demand for natural/herbal products as well due their low level of side effects, cost efficiency and multiple inhibition properties. Based on this, present research works with an objective examine bioactive components, vitro anti-inflammatory vivo antiinflammatory behaviour...

Gene therapies have enormous potential to cure human disease. In recent years, hematopoiet‐ ic stem cell (HSC) gene therapy has advanced tremendously, due in part to years of intense re‐ search to develop effective vectors and efficient ex vivo transduction protocols. In early clinical trials, inefficient gene transfer resulted in either a lack of therapeutic benefit or shortlived therapeutic b...

Background: Cadmium is one of the most toxic heavy metals in our environment having a very strong ability to accumulate in body organs, especially in kidney. The present study was done to determine the genotoxicity and cytotoxicity in kidneys of rats exposed to cadmium. Methods: Male rats (n=30), kept in standard conditions were used in this study. The animals were randomly divided into 2 group...

This review document addresses the processes of DNA damage, repair and mutation as key steps on the pathway towards cancer development and also briefly describes the most common genotoxicity tests used in the evaluation of whether a compound is genotoxic or not. Knowledge that the carcinogen under evaluation is genotoxic or nongenotoxic is a vital stage of the risk assessment and influences the...

Tests for genotoxic or mutagenic effects of chemicals have prompted efficient biostatistical methods for the quantification of dose-response data, especially from the Ames Salmonella/microsome assay. A decision about the genotoxicity of a compound is, however, always based on several assays, and results from multiple or repeated genotoxicity assays have to be combined either qualitatively or, e...

Fluphenazine, an antipsychotic drug that belongs to the phenothiazine family, reduced the genotoxicity of direct- and indirect-acting mutagens in the Ames test, both in the presence and in the absence of promutagen-activating S9 fraction. In short-term tests on human lymphocytes, the inhibitory effect of fluphenazine on the genotoxicity of standard mutagens was strongest in the cytokinesis-bloc...