Gestational trophoblastic neoplasia (GTN) describes a heterogeneous group of interrelated lesions that arise from abnormal proliferation of placental trophoblasts. GTN lesions are histologically distinct, malignant lesions that include invasive hydatidiform mole, choriocarcinoma, placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT). GTN tumors are generally highly...

a Department of Obstetrics and Gynecology, University of Hong Kong, Queen Mary Hospital, Hong Kong, China b Departments of Histopathology and Medical Oncology, Charing Cross Trophoblastic Disease Center, Charing Cross campus of Imperial College London, London, UK c Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institu...

Gestational trophoblastic disease has been reported to be responsive to chemotherapy, with a 90% cure rate. Several factors place patients at high risk of experiencing treatment failure with single agent chemotherapy. Choriocarcinoma following term pregnancy is very rare and associated with a poor prognosis and a mortality rate of 33-40%. We present a rare case of cutaneous metastasis of chorio...

Placental site trophoblastic tumour (PSTT) is a rare form of trophoblastic disease accounting for < 2% of all gestational trophoblastic neoplasms. Most of the cases follow a normal pregnancy and a small number have a preceeding molar pregnancy or spontaneous abortion. It can occur as early as several weeks or as late as 15 years after normal delivery, molar pregnancy or abortion. Excessive inte...

BACKGROUND Klippel-Trenaunay syndrome is a non-heritable venous malformation with bone and soft tissue hypertrophy and cutaneous nevi. CASE CHARACTERISTICS Neonate with Klippel Trenaunay syndrome born to a mother with past history of Gestational trophoblastic neoplasm. OBSERVATION Antenatally, a fetal vascular malformation was identified ultrasonologically at 29 weeks gestation. Acute myelo...

Early recognition of Gestational Trophoblastic Neoplasm (GTN) will maximize the chances of cure with chemotherapy but some patients present with many different symptoms months or even years after the causative pregnancy making diagnosis difficult. Clinicians should be aware of the possibility of GTN in any reproductive age woman with bizarre central nervous system, gastrointestinal, pulmonary s...

Gestational trophoblastic disease (GTD) is characterized by abnormal proliferation of pregnancy-associated trophoblastic tissue with malignant potential. GTD covers a spectrum of tumors and tumor-like conditions and may occur in a benign form as hydatiform mole or as malignancy in the form of invasive mole or choriocarcinoma. GTD has become a curable malignant disease since the introduction of ...

The reported incidence of gestational trophoblastic disease is 1-2:1000 pregnancies. The disease includes a) hydatidiform mole (partial and complete), b) invasive mole, c) choriocarcinoma and d) placental site trophoblastic tumors. Current management is based on several prognostic risk factors. We describe an interesting case of a 51-year–old woman who presented with abnormal vaginal bleeding a...

The World Health Organisation’s (WHO) classification of gestational trophoblastic disease includes complete, partial, invasive and metastatic hydatidiform mole, exaggerated placental site nodule or plaque and two malignant tumoursplacental site trophoblastic tumour and choriocarcinoma [1]. The incidence of gestational trophoblastic disease (GTD) in Sri Lanka according to a hospital based study ...

Background Gestational trophoblastic disease (GTD) defines a heterogenenous group of interrelated lesions that arise from the trophoblastic epithelium of the placenta. There are several histologically distinct types of GTD: hydatiform mole (complete or partial), persistant/invasive gestational trophoblastic neoplasia (GTN), choriocarcinoma and placenta site trophoblastic tumors. The aim of this...