Tec, the prototypical member of the Tec family of tyrosine kinases, is abundantly expressed in T cells and other hemopoietic cell types. Although the functions of Itk and Txk have recently been investigated, little is known about the role of Tec in T cells. Using antisense oligonucleotide treatment to deplete Tec protein from primary T cells, we demonstrate that Tec plays a role in TCR signalin...

As with most computer science problems, representation of the data is the key to ecient and eective solutions. Piecewise linear representation has been used for the representation of the data. This representation has been used by various researchers to support clustering, classication, indexing and association rule mining of time series data. A variety of algorithms have been proposed to obtain...

In the present work we use the NASA-JPL global ionospheric maps of total electron content (TEC), firstly to construct TEC maps (TEC vs. magnetic local time MLT, and magnetic latitude MLAT) in the interval from 1999 to 2005. These TEC maps were, in turn, used to estimate the annualto-mean amplitude ratio, A1, and the semiannual-to-mean amplitude ratio, A2, as well as the latitudinal symmetrical ...

Among cytoplasmic protein-tyrosine kinases (PTKs) Tec now forms a novel subfamily with recently identified Tec-related PTKs (Btk and Itk/Tsk). Tec is known to be abundantly expressed in myeloid cells, and multiple forms of Tec protein can be generated via the mechanism of alternative splicing. In this report, we have investigated 5'-terminal diversity of the tec messages to demonstrate a predom...

Tumour-specific chromosomal rearrangements are known to create chimaeric products with the ability to generate many human cancers. hTAF(II)68-TEC (where hTAF(II)68 is human TATA-binding protein-associated factor II 68 and TEC is translocated in extraskeletal chondrosarcoma) is such a fusion product, resulting from a t(9;17) chromosomal translocation found in extraskeletal myxoid chondrosarcomas...

Cleaning validation, a requirement of the current Good Manufacturing Practices (cGMP) for Drugs, consists of documented evidence that cleaning procedures are capable of removing residues to predetermined acceptance levels. This report describes a strategy for the selection of the worst case product for the production of lyophilized reagents (LRs) for labeling with 99mTc from the Instituto de Pe...

An innovative micro-test structure for detecting the thermal expansion coefficient (TEC) of metal materials is presented in this work. Throughout this method, a whole temperature sensing moveable structures are supported by four groups of cascaded chevrons beams and packed together. Thermal expansion of the metal material causes the deflection of the cascaded chevrons, which leads to the capaci...

To obtain accurate measurements for brightness temperature from the IIP radiometer, it is necessary to know the temperature of the front-end components especially low noise amplifier (LNA) and microwave terminator during measurements. For this application, all of these components will be placed on a temperature-stabilized metal plate which can be achieved by using a thermoelectric cooler (TEC)....

Myeloablative conditioning before bone marrow transplantation (BMT) results in thymic epithelial cell (TEC) injury, T-cell immune deficiency, and susceptibility to opportunistic infections. Conditioning regimen-induced TEC damage directly contributes to slow thymopoietic recovery after BMT. Keratinocyte growth factor (KGF) is a TEC mitogen that stimulates proliferation and, when given before co...

fuzzy time series have been developed during the last decade to improve the forecast accuracy. many algorithms have been applied in this approach of forecasting such as high order time invariant fuzzy time series. in this paper, we present a hybrid algorithm to deal with the forecasting problem based on time variant fuzzy time series and particle swarm optimization algorithm, as a highly effici...