a young woman with no history of diabetes tried to commit suicide by injecting 2800 units of subcutaneous nph insulin. she was transferred to loghman hospital within 12 hours. the main clinical symptom was continuous seizure activity which was resistant to all forms of routine drug therapy. the patient was treated with intravenous hypertonic glucose (50%) followed by continuous glucose (10%) in...

in this case study, we describe a 25 year-old male who showed the symptoms of diabetes after a period of heavy drinking. (hba1c=13%). treatment was started with 120 units of insulin. after stopping alcohol consumption and taking an appropriate diet, insulin was tapered down. five months after the start of treatment, insulin was stopped (hba1c=5%). the results showed that he was in a good metabo...

background: untreated or poorly controlled gestational diabetes can cause serious complications for mother and newborn. glibenclamide is rarely used in treating mothers with this disease. this study aimed at comparing the effect of glibenclamide and insulin on neonatal outcomes in women with gestational diabetes mellitus. methods: in this randomized controlled clinical trial, 249 pregnant women...

Inhalational insulin was withdrawn from the market due to its potential to produce airway hyper-reactivity and bronchoconstriction. So the present study was designed to explore the acute effects of insulin on airway reactivity of guinea pigs and protective effects of salbutamol and ipratropium against insulin induced airway hyper-responsiveness on isolated tracheal smooth muscle of guinea pig. ...

new-onset hyperglycemia in patients admitted to intensive care units increases the risk of morbidity and mortality. insulin resistance is frequently seen in the treatment of stress-induced hyperglycemia. metformin, an oral anti-hyperglycemic agent, may introduce a new treatment protocol in critically ill patients with insulin-resistance hyperglycemia. fifty-one non-diabetic traumatized patients...

Insulin resistance is a condition in which insulin signaling and action are impaired in insulin sensitive tissues and results in hyperglycemia, hyperlipidemia and type 2 diabetes mellitus. Our previous studies have shown that rosa damascena has antihyperglycemic effects on diabetic and normal rats. Therefore, we conducted a study to evaluate the effect of this medicinal plant on insulin sensiti...

Amyloidosis consists of approximately 30 protein-folding disorders in which a specific soluble precursor protein aggregates to form the insoluble fibrils amyloid. Insulin is hypothesized localized cutaneous insulin-derived (AIns) amyloidosis. Amyloid deposition at insulin injection sites can interfere with absorption, leading poor glucose control. Despite increasing prevalence diabetes mellitus...

ABSTRACT: Camel milk contains sufficient levels of insulin and does not form the coagulum in the stomach preventing degradation of insulin and act as an effective vehicle to take the milk insulin unchanged to the intestine. In present study direct spectroscopy and standard addition method, well-known methods in analytical chemistry were used for determining insulin concentration in camel milk. ...