OBJECTIVE Sulfonylureas have historically been analyzed as a medication class, which may be inappropriate given the differences in properties inherent to the individual sulfonylureas (hypoglycemic risk, sulfonylurea receptor selectivity, and effects on myocardial ischemic preconditioning). The purpose of this study was to assess the relationship of individual sulfonylureas and the risk of overa...

The aim of the present study was to develop a sustained release monolithic system for the low solubile/low dose glipizide, for the treatment of type II diabetes mellitus. The matrices were prepared by dry blending of polymers hydroxy propyl methyl cellulose (HPMC) or erodible Eudragit (ammonio methacrylate copolymers) and other excipients using direct compression method and were characterized u...

GLIPIZIDE, a sulphonyl-cyclohexylurea derivative, was introduced in 1971. It was found to be a hypolycaemic of great potency, short action and low toxicity. This report is concerned with the results following treatment for one year with the drug in a diabetic clinic in Belfast. The study particularly examined the effect of the drug on patients of differing degrees of obesity and also examined t...

The crystal structure of glipizide, used as a major treatment of type-2 diabetes, has been determined ab initio using variable-temperature laboratory X-ray powder diffraction combined with a direct-space Monte Carlo/simulated annealing methodology. The strengths of the intermolecular interactions (van der Waals, pi-pi stacking, hydrogen bonding and steric interlock) were quantitatively estimate...

evere, long-term hypoglycemia induced y co-trimoxazole in a patient ith predisposing factors and Sundays. His clinical history included high blood pressure treated with candesartan 16 mg/day, type 2 diabetes mellitus treated with glipizide 5 mg/8 h, which he had not taken for 4 days, dyslipidemia treated with gemfibrozil aded from http://www.elsevier.es, day 20/09/2017. This copy is for persona...

BACKGROUND As arterial thrombosis accounts for the vast majority of cardiovascular complications in obese, insulin resistant patients, we hypothesized that improving insulin sensitivity may be effective in reducing the thrombotic response following vascular injury. OBJECTIVES We investigated the effect of the thiazolidinedione drug, pioglitazone, on the thrombotic response to injury in obese,...

We performed a network meta-analysis to compare the efficacy of 12 single-drug regimens (Glibenclamide, Glimepiride, Pioglitazone, Rosiglitazone, Repaglinide, Metformin, Sitaglitin, Exenatide, Liraglutide, Acarbose, Benfluorex, and Glipizide) in the treatment of type 2 diabetes mellitus (T2DM). Fifteen relevant randomized controlled trials (RCTs) were included; direct and indirect evidence from...