BACKGROUND Multiple factors influence timing of dialysis initiation. The impact of supply of nephrology workforce on timing and incidence of dialysis initiation is not well known. METHODS We determined the number of pediatric and adult nephrologists in each state using data from the American Medical Association and American Boards of Internal Medicine and Pediatrics. We ascertained state popu...

The question when to initiate dialysis is attracting increasing attention. In recent years, there has been a tendency to initiate dialysis earlier in terms of estimated glomerular filtration rate (eGFR) in an attempt to achieve better patient outcomes. However, several observational studies and one randomized controlled trial have found no benefit for early dialysis initiation. On the contrary,...

Blood filtration in the kidney glomerulus is essential for physiological homeostasis. The filtration apparatus of the kidney glomerulus is composed of three distinct components: the fenestrated endothelial cells, the glomerular basement membrane, and interdigitating foot processes of podocytes that form the slit diaphragm. Recent studies have demonstrated that podocytes play a crucial role in b...

The effects of captopril on effective renal plasma flow and glomerular filtration rate were studied using a noninvasive radioisotopic method on individual kidneys in eight patients with renovascular hypertension and 12 patients with essential hypertension with various renin levels. Four patients with renovascular hypertension had unilateral while three had bilateral renal artery stenosis. The e...

BACKGROUND Point-of-care testing for creatinine using a fingerprick sample and resultant estimated glomerular filtration rate has potential for screening for chronic kidney disease in community settings. This study assessed the applicability of the Nova StatSensor creatinine analyzer for this purpose. METHODS Fingerprick samples from 100 patients (63 renal, 37 healthy volunteers; range 46-962...

http://bmj.com/cgi/content/full/333/7571/733 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/333/7571/733/DC1 "References" References http://bmj.com/cgi/content/full/333/7571/733#otherarticles 6 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/333/7571/733#BIBL This article cites 25 articl...

The uniqueness of carboplatin as a chemotherapy drug is in the fact that the systemic drug exposure produced by any dose in a patient can be reasonably estimated on the basis of his or her renal function. Calvert’s formula (1) of delivering a calculated dose in terms of target carboplatin area under the time– concentration curve (AUC) and a measured or estimated glomerular filtration rate (GFR)...

Thomson, Scott C., Volker Vallon, and Roland C. Blantz. Kidney function in early diabetes: the tubular hypothesis of glomerular filtration. Am J Physiol Renal Physiol 286: F8–F15, 2004; 10.1152/ajprenal.00208.2003.—At the onset of diabetes mellitus, the glomerular filtration rate becomes supranormal. Discovery science has identified many abnormalities in the early diabetic kidney that apparentl...

Correlation and concordance of glomerular filtration rate from renal scintigraphy modified modification diet in disease equation