نتایج جستجو برای: glu298asp polymorphism
تعداد نتایج: 107378 فیلتر نتایج به سال:
BACKGROUND Preeclampsia, the most common serious complication of pregnancy, is characterized by vasoconstriction, dysfunction of the vascular endothelium, and hypertension. Unidentified genetic factors and impaired nitric oxide (NO)-mediated vasodilation are thought to contribute to the development of the syndrome. Polymorphisms of the endothelial nitric oxide synthase (eNOS) gene affect NO pro...
To the Editor: Development of end stage renal disease (ESRD) and a blunted in vitro generation of nitric oxide (NO) have been recently associated with the 298Asp substitution in the endothelial NO synthase (eNOS) gene.1 Diabetic nephropathy was the culprit of ESRD in most patients (pts);1 however, the same association was recently reported in pts with ESRD due to polycystic kidney disease.2 Col...
BACKGROUND AND AIM Three NOS isoforms are responsible for nitric oxide production in various tissues. Endothelial constitutive NOS is expressed in vascular endothelium and in platelets, contributing to vascular tone regulation and platelet aggregation. The aim of the present work was to examine eNOS polymorphism, to find a correlation with platelet NO production and degree of insulin resistance...
Background: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) mediates a large range of processes, and abnormality in the production of NO has been implicated in diabetic complications including diabetic nephropathy (DN). G894T polymorphism in the eNOS gene has been shown to decreased activity the NO levels of plasma. The association between eNOS Glu298Asp gene polymorphism and DN ri...
سابقه و هدف: عوامل ژنتیکی با بیماری گرفتگی عروق کرونر در ارتباط هستند. در بین چندین پلی مورفیسم ژن نیتریک اکساید سنتاز اندوتلیالی، واریته glu298asp در بیماری گرفتگی عروق کرونر نقش دارد. هدف از مطالعه اخیر بررسی ارتباط بین ریسک ابتلا به بیماری گرفتگی عروق کرونر و پلی مورفیسم glu298asp در ژن نیتریک اکساید سنتاز اندوتلیالی می باشد. روش بررسی: در این مطالعه مورد- شاهدی، 91 بیمار ایرانی دچار گرفتگی ...
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