Abstract The present study was performed to investigate the effects of dietary yeast β-1,3/1,6-D-glucans supplemented over a 14-day feeding period on liver and cardiac function oxidative mechanism underlying these effects. We assessed relevant lipid peroxidation protein oxidation biomarkers, antioxidant defense indices [superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), per...

BACKGROUND Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we invest...

The majority of carbohydrates found in edible mushroom are the form polysaccharides, specifically beta-glucans. These beta-glucans have been reported as anticancer, antioxidant, and immunomodulator. This study aimed to investigate potential P. pulmonarius functional food by comparing carbohidrate content (total carbohydrate, beta-glucans, reducing sugars) extracted using microwave assisted extr...

Hypercholesterolemia is one of primary risk factors of cardiovascular disease, together with metabolic syndrome, hypertension and diabetes. Although progress has been made, the search for novel methods of preventing and treating dyslipidemia is ongoing and current therapies for cardiovascular disease induce various side effects. β‑glucans are linear unbranched polysaccharides found in various n...

Fluorescence microscopy was used to determine the l ocation of Bglucans in sorghum. Sections from three genetically different sorghum cultivars were st ained with Calcofluor or Congo Red , fluorochromes which have been reported to react with 13-glucans. Autofluorescence, indicative of ferulic acid in other cereals, was observed in untreated sections. When stained sections were treated with endo...

Dectin 1 is a mammalian cell surface receptor for (133)-D-glucans. Since (133)-D-glucans are commonly present on fungal cell walls, it has been suggested that dectin 1 is important for recognizing fungal invasion. In this study we tried to deduce the amino acid residues in dectin 1 responsible for -glucan recognition. HEK293 cells transfected with mouse dectin 1 cDNA could bind to a gel-forming...

Glucans are polymers of d-glucose with differing linkages in linear or branched sequences. They are constituents of microbial and plant cell-walls and involved in important bio-recognition processes, including immunomodulation, anticancer activities, pathogen virulence, and plant cell-wall biodegradation. Translational possibilities for these activities in medicine and biotechnology are conside...

OBJECTIVES Hormones and cytokines are known to act as regulatory messengers between the neuroendocrine and immune systems. The innate immune system identifies infectious agents by means of pattern-recognition receptors. These receptors recognize pathogen-specific macromolecules called pathogen-associated molecular patterns. Fungal cell wall glucans nonspecifically stimulate various aspects of i...

Among the biopolymers of nature, the high-molecular-weight glucans are probably the most widely distributed. These homopolysaccharides with aand p1,4-, 1,3-, and 1,64nkages account for huge quantities of such natural substances as starch, cellulose, pseudonigeran, curdlan and paramylon, dextran, and pustulan. All of these polymers are either naturally crystalline or can be easily induced to cry...

The attenuated strain of Mycobacterium bovis Bacille Calmette-Guérin (BCG), used worldwide to prevent tuberculosis and leprosy, is also clinically used as an immunotherapeutic agent against superficial bladder cancer. An anti-tumor polysaccharide has been isolated from the boiling water extract of the Tice substrain of BCG and tentatively characterized as consisting primarily of repeating units...