Peroxisome proliferator-activated receptor-gamma (PPARgamma) are ligand-activated transcription factors that regulate cell growth, inflammation, lipid metabolism, and insulin sensitivity. We recently demonstrated that PPARgamma agonists limit high glucose-induced inflammation in a model of proximal tubular cells (PTC; Panchapakesan U, Pollock CA, and Chen XM. Am J Physiol Renal Physiol 287: F52...

Glucose metabolism in mammalian thymocytes is coupled to their development and selection in the thymus. In chickens, thymocytes develop in a low glucose concentration in ovo and a high glucose concentration posthatch. To determine the effect of glucose concentration on thymocyte glucose metabolism, embryonic thymic lobes were cultured in media containing varying glucose concentrations and thymo...

Dopaminergic signaling is one of the regulatory pathways being investigated for its implication in glucose metabolism. The aim of this study was to determine the effect of cabergoline on biochemical and anthropometric parameters in prediabetes stage (impaired fasting glucose and impaired glucose tolerance). In this double blind, placebo-controlled, pilot study, 27 prediabetic adults were random...

Release of glucose by liver and kidney are both increased in diabetic animals. Although the overall release of glucose into the circulation is increased in humans with diabetes, excessive release of glucose by either their liver or kidney has not as yet been demonstrated. The present experiments were therefore undertaken to assess the relative contributions of hepatic and renal glucose release ...

Background: Data on safety degree and anti–type 1 diabetic effects of Pterocarpus soyauxii Taub are known, but not type 2 diabetes yet. Objective: To evaluate preventive P. aqueous stem bark extract dexamethasone–induced insulin resistance oxidative stress in rat. Materials Methods: Glucose-overloaded normal Wistar rats were administered with plant at various doses (38–300 mg.kg) a si...

Indirect calorimetry and primed constant infusion of [U-13C]glucose were combined in 16 appropriate-for-gestational age newborn, parenterally fed infants, in order to measure glucose utilization and glucose oxidation respectively. Glucose intake ranged between 10.0 and 24.1 g day-1 kg-1 and energy intake between 156.9 and 439.3 kJ day-1 kg-1. Glucose utilization (P less than 0.001), glucose oxi...

new-onset diabetes after transplantation (nodat) is one of the frequent complications following kidney transplantation. patients were randomized to receive cyclosporine a- or tacrolimus-based immunosuppression. fasting and oral glucose tolerance tests were performed, and the patients were assigned to one of the following three groups based on the results: normal, impaired fasting glucose/impair...

To study the impact of exercise or fasting and of subsequent glucose supplementation on glucose metabolism in rats, a spectrophotometric method was used to determine peripheral blood glucose; a technique associating (1)H-NMR spectroscopy and cortical microdialysis was also used to observe intra- plus extracellular and extracellular brain glucose variations, respectively. Compared with control a...

Background: Several studies have emphasized the importance of cardiovascular disease (CVD) prevention. However, there is a dearth of data on the prevention of cardiovascular disease recurrence. The present study was the 1st in Iran to evaluate factors associated with CVD recurrence. Methods: This prospective cohort study was conducted on 483 subjects (> 30 years old) with a history of CVD who p...