Glucose is the main source of energy for the body, requiring constant regulation of its blood concentration. Insulin release by the pancreas induces glucose uptake by insulin-sensitive tissues, most notably the brain, skeletal muscle, and adipocytes. Patients suffering from type-2 diabetes and/or obesity often develop insulin resistance and are unable to control their glucose homeostasis. New i...

Diabetes Mellitus (DM) is an incurable disease that can be prevented clinically from worsening. This based on classification related to pancreatic damage in total or partial so the impact insulin production. Glucose transporter a protein glucose uptake outside cell into and provides important role body's homeostasis. transporter-2 (GLUT-2) found pancreas, liver, kidney. Parameters used are expr...

Sodium-glucose co-transporter 2 (SGLT2) inhibitors may decrease risk of renal function deterioration and proteinuria progression but, there are little clinical data about the comparison between dapagliflozin (DAPA) versus empagliflozin (EMPA) in patients with diabetes mellitus (DM) over one year time. Inhere,we directly compare effectiveness two distinct sodium-glucose co-transporter2 (SGLT2I) ...

Glucose transporters are membrane-embedded proteins that mediate the uptake of glucose from the surrounding medium into the cell. Glucose is the main fuel for most cells, and its uptake is rate-limiting for glucose utilization. For this reason, it is expected that glucose transport is tightly regulated. Whereas rapid regulation of glucose transporters by hormones has been known for some time, t...

abstract objective: globally, 3-5.2 percent of people suffer from diabetes which is one of the most serious metabolic disorders resulting in an increase in inflammatory biomarkers e.g. interleukin-6, tumor necrosis factor-alpha, and c-reactive protein. the aim of this study was to investigate the relationship between inflammation, oxidative stress and fasting blood glucose, lipid profile and an...

background and aim: the aim of this study was to determine the effect of legume intake in therapeutic lifestyle change (tlc) on fasting insulin, fasting blood glucose, hba1c and homeostasis model assessment insulin resistance (homa-ir) in patients with type 2 diabetes. materials and methods: in this randomized crossover trial, 31 subjects with type 2 diabetes in the age range of 50 to 80 years ...

Recently, the idea has been developed to lower blood glucose blood glucose levels in diabetes by inhibiting sugar reabsorption sugar reabsorption in the kidney kidney . The main target is thereby the early proximal tubule proximal tubule where secondary active transport secondary active transport of the sugar is mediated by the sodium-D: -glucose D-glucose cotransporter SGLT2 SGLT2 . A model su...