نتایج جستجو برای: glutathione cycle
تعداد نتایج: 314075 فیلتر نتایج به سال:
To investigate how high light affects the responses of photosynthesis to heat stress, the effects of high temperature (25-42.5 degrees C) either in the dark or in the light (1000 micromol m(-2) s(-1)) on photosystem II (PSII) photochemistry and the xanthophyll cycle were investigated in rice plants. At temperatures higher than 35 degrees C, there was a decrease in the CO(2) assimilation rate, a...
resistance of the weanling rat to acetaminophen (ap ap)-induced hepatotoxicity is manifested with regard to a surge in apap-glutathione (osh) conjugate formation in the liver [allameh et al. mech aging dev 95(1997)71]. the present study was conducted to assess the role of this detoxification pathway in apapinduced lipid per6xidationin the liver. lipid peroxidation measured as thiobarbituric aci...
BACKGROUNDS Glutathione is an endogenous redox couple in animal cells and plays important roles in antioxidant defense and detoxification, although it is unknown if oral glutathione supplementation affects exercise-induced physiological changes. The present study investigated the effect of glutathione intake on exercise-induced muscle metabolism and fatigue in mice and humans. METHODS ICR mic...
Background: Alteration in oxidative and nitrosative stress as well as antioxidant status is known to occur in carcinogenesis and during treatment of cancer with chemotherapeutic drugs. Objective: The objective of this study was to evaluate the serum levels of reduced glutathione (GSH) glutathione-stransferase (GST) and nitric oxide (NO • ) in post-operative stage II breast cancer patients under...
Cisplatin is a potent cytotoxic agent that functions as a bivalent electrophile, forming both interstrand and intrastrand DNA cross-links. Cisplatin-mediated DNA damage results in cell cycle arrest and initiation of apoptotic cell death. Increased cellular glutathione concentrations have been closely correlated with cisplatin resistance but do not reduce the extent of cisplatin-DNA adduct forma...
Cisplatin is a potent cytotoxic agent that functions as a bivalent electrophile, forming both interstrand and intrastrand DNA cross-links. Cisplatin-mediated DNA damage results in cell cycle arrest and initiation of apoptotic cell death. Increased cellular glutathione concentrations have been closely correlated with cisplatin resistance but do not reduce the extent of cisplatin-DNA adduct forma...
The aim of the study was to monitor the effects of exogenous melatonin on cucumber (Cucumis sativus L.) chloroplasts and explore the mechanisms through which it mitigates chilling stress. Under chilling stress, chloroplast structure was seriously damaged as a result of over-accumulation of reactive oxygen species (ROS), as evidenced by the high levels of superoxide anion (O2-) and hydrogen pero...
Cassava (Manihot esculenta) is the most important root crop in the tropics, but rapid postharvest physiological deterioration (PPD) of the root is a major constraint to commercial cassava production. We established a reliable method for image-based PPD symptom quantification and used label-free quantitative proteomics to generate an extensive cassava root and PPD proteome. Over 2600 unique prot...
Methods Bovine microvascular endothelial cells (MEC) were able to degrade the H202 generated by phorbol myristate acetate-activated bovine neutrophils or by glucose oxidase with a maximal capacity of 4.0±1.2 (SD) nmol/10' cells/min, corresponding to the H202 released by about 3 X 10' neutrophils. H202 degradation occurred via the glutathione redox cycle and catalase. Degradation via the glutath...
Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism.
Mitochondrial dysfunction affects cellular energy metabolism, but less is known about the consequences for cytoplasmic biosynthetic reactions. We report that mtDNA replication disorders caused by TWINKLE mutations-mitochondrial myopathy (MM) and infantile onset spinocerebellar ataxia (IOSCA)-remodel cellular dNTP pools in mice. MM muscle shows tissue-specific induction of the mitochondrial fola...
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