The beneficial effects of exercise on certain types of diabetes mellitus have long been recognized. Occasionally a young and active diabetic, with a stable glycemia, controlled by diet and insulin, develops severe and sometimes prolonged insulin reactions following participation in strenuous sports; while other young and equally active diabetics, with an unstable glycemia, find participation in...

OBJECTIVE Hyperglycemia is a common condition in hospitalized patients. The aim of this study was to investigate the relationships between glycemia upon admission and mortality in a heterogeneous group of adult patients. RESEARCH DESIGN AND METHODS The 3-year records released from a general hospital were associated with a plasma glucose dataset of its general laboratory. A matched case-contro...

BACKGROUND Sleep plays an important role in health, and poor sleep is associated with negative impacts on diabetes management, but few studies have objectively evaluated sleep in adults with type 1 diabetes mellitus (T1DM). Nocturnal glycemia and sleep characteristics in T1DM were evaluated using body-worn sensors in real-world conditions. METHODS Analyses were performed on data collected by ...

This pre-clinical study investigated the transient receptor potential ankyrin-1 (TRPA1) channels on modulating targets for glucose homeostasis using agonists: electrophilic agonists, cinnamaldehyde (CIN) and allyl isothiocyanate (AITC), non-electrophilic agonist, carvacrol (CRV). A tolerance test was performed rats. CIN AITC (5, 10 20 mg/kg) or CRV (25, 100, 300, 600 were administered intraperi...

This is the first of three articles dealing with the International Diabetes Federation meeting, which was held in Paris, 24–29 August 2003. Michael Stumvoll (Tübigen, Germany) gave the Minkowski lecture, discussing aspects of the control of glycemia, illustrating the “hyperbolic law of glucose control,” depicting the inverse relationship between insulin secretion and insulin sensitivity. If one...

Islet beta-cells are the regulatory element of the glucose homeostasis system. When functioning normally, they precisely counterbalance changes in insulin sensitivity or beta-cell mass to preserve normoglycemia. This understanding seems counter to the dogma that beta-cells are regulated by glycemia. We studied 60% pancreatectomy rats (Px) 4 wk postsurgery to elucidate the beta-cell adaptive mec...

BACKGROUND Hyperglycemia and acute kidney injury (AKI) are common in critically ill children and have been associated with higher morbidity and mortality. The incidence of AKI in children is difficult to estimate because of the lack of a standard definition for AKI. The pediatric RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease) criteria can be used to define ...

OBJECTIVE This national, population-based study reports diabetes incidence based on oral glucose tolerance tests (OGTTs) and identifies risk factors for diabetes in Australians. RESEARCH DESIGN AND METHODS The Australian Diabetes, Obesity and Lifestyle Study followed-up 5,842 participants over 5 years. Normal glycemia, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diab...

OBJECTIVE Various methods are used to quantify postprandial glycemia or glucose variability, but few have been compared and none are standardized. Our objective was to examine the relationship among common indexes of postprandial glycemia, overall hyperglycemia, glucose variability, and A1C using detailed glucose measures obtained during everyday life and to study which blood glucose values of ...

Hemoglobin A1c (HbA1c) is widely used as an index of mean glycemia, a measure of risk for the development of diabetes complications, and a measure of the quality of diabetes care. Emerging literature suggests that, although HbA1c levels change little over time within persons without diabetes, they vary considerably among individuals, suggesting that factors other than glycemia may impact HbA1c....