نتایج جستجو برای: glycogen
تعداد نتایج: 18964 فیلتر نتایج به سال:
BACKGROUND The Pacific oyster Crassostrea gigas is an important cultivated shellfish that is rich in nutrients. It contains high levels of glycogen, which is of high nutritional value. To investigate the genetic basis of this high glycogen content and its variation, we conducted a candidate gene association analysis using a wild population, and confirmed our results using an independent populat...
Glycogen is the major mammalian glucose storage cache and is critical for energy homeostasis. Glycogen synthesis in neurons must be tightly controlled due to neuronal sensitivity to perturbations in glycogen metabolism. Lafora disease (LD) is a fatal, congenital, neurodegenerative epilepsy. Mutations in the gene encoding the glycogen phosphatase laforin result in hyperphosphorylated glycogen th...
Protein targeting to glycogen (PTG) is a scaffolding protein that targets protein phosphatase 1alpha (PP1alpha) to glycogen, and links it to enzymes involved in glycogen synthesis and degradation. We generated mice that possess a heterozygous deletion of the PTG gene. These mice have reduced glycogen stores in adipose tissue, liver, heart, and skeletal muscle, corresponding with decreased glyco...
1. The administration of cortisol and of other glucocorticoid steroids to starved mice produced an increase in liver glycogen content, an elevation of glycogen-synthetase activity and a predominantly particulate localization of both phosphorylase and glycogen-synthetase enzymes. 2. Three daily doses of actinomycin D caused a marked glycogen depletion, a significant decrease in glycogen-syntheta...
Preservation of the nutritional value fish and useful qualities its rich composition is extremely important. The urgent task food industry to develop create quality products that meet modern production trends compete in domestic foreign markets. This scientific paper describes studies aimed at assessing specific weight (%) essential nutrients (glycogen, proteins, lipids) particular organs tissu...
In the brain, glycogen metabolism has been implied in synaptic plasticity and learning, yet the distribution of this molecule has not been fully described. We investigated cerebral glycogen of the mouse by immunohistochemistry (IHC) using two monoclonal antibodies that have different affinities depending on the glycogen size. The use of focused microwave irradiation yielded well-defined glycoge...
Glycogen is present in all tissues, but it primarily stored the liver and muscle. As a branched chain carbohydrate, broken down by phosphorylase debrancher enzymes, which are cytoplasmic. It also degraded lysosomal α-glucosidase (GAA) known as acid α-glucosidase. The deficiency of GAA patients Pompe disease, phenotypes infantile, juvenile later onset forms. disease treated enzyme replacement th...
1. Rat liver glycogen was separated into fractions of relatively uniform particle sizes by large volume rate-zonal centrifugation of tissue homogenates with the use of sucrose density gradients. 2. After centrifugation, the distribution curve obtained by plotting the glycogen content of all collected fractions exhibited its maximum a short centrifugal distance from the zone which contained the ...
Under physiological conditions, most neurons keep glycogen synthase (GS) in an inactive form and do not show detectable levels of glycogen. Nevertheless, aberrant glycogen accumulation in neurons is a hallmark of patients suffering from Lafora disease or other polyglucosan disorders. Although these diseases are associated with mutations in genes involved in glycogen metabolism, the role of glyc...
objective(s): stem cell therapy is believed to be as a promising treatment strategy for tissue repair and regeneration. the plasticity specification of the adult stem cells, such as mscs, has enabled that these cells to be used in the treatment of a broad spectrum of diseases like liver disorders. in this study, the production of urea and albumin (alb), glycogen storage, and expression of some ...
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