نتایج جستجو برای: glycosylated protein
تعداد نتایج: 1244008 فیلتر نتایج به سال:
Here, we provide direct evidence that using recombinant proteins expressed in eukaryotic cells as antigen is a practical way to generate monoclonal antibodies (mAbs) against heavily glycosylated proteins. Heavily glycosylated proteins are typically difficult targets for mAb generation, being limited by unsatisfactory affinity and low specificity. Using the heavily glycosylated CD45 protein as a...
The variant-specific surface protein of Giardia, VSP4A1, is a glycosylated and palmitoylated protein
Plants are rich in secondary metabolites, which often useful as a relevant source of nutraceuticals. Quercetin (QUE) is flavonol aglycone able to bind Transthyretin (TTR), plasma protein that under pathological conditions can lose its native structure leading fibrils formation and amyloid diseases onset. Here, the dual nature five quercetin 3-O-glycosylated derivatives, isolated from different ...
Beta 2 glycoprotein I (β2GPI) is a single chain 50 kDa highly glycosylated glycoprotein at an approximate concentration of 4 μM in cells. The abundance of this protein in plasma and its high state of preservation indicate the important role of this protein in mammalian. In addition, β2GPI has a particular structure in the fifth domain, and is categorized as the major antigen recognized by autoa...
BACKGROUND Although the occurrence, biosynthesis and possible functions of glycoproteins are increasingly documented for pathogens, glycoproteins are not yet widely described in probiotic bacteria. Nevertheless, knowledge of protein glycosylation holds important potential for better understanding specific glycan-mediated interactions of probiotics and for glycoengineering in food-grade microbes...
Hydrogels made of crosslinked macromolecules used in regenerative medicine technologies can be designed to affect the fate surrounding cells and tissues defined ways. Their function typically depends on type number bioactive moieties such as receptor ligands present hydrogel. However, detail how are presented also instrumental. In this work, crosslinking architecture a hydrogel its bioactivity ...
In several Leishmania species, glycosylated inositol phospholipids exist as free lipids, as membrane protein anchors, and as the membrane-binding moieties of the lipophosphoglycans. Both the glycolipid-anchored cell surface metalloproteinase, gp63, and the lipophosphoglycans have been proposed to be involved in cell invasion. Moreover, the lipophosphoglycans have been implicated in the survival...
Protein-carbohydrate interactions are important for glycoprotein structure and function. Antibodies of the IgG class, with increasing significance as therapeutics, are glycosylated at a conserved site in the constant Fc region. We hypothesized that disruption of protein-carbohydrate interactions in the glycosylated domain of antibodies leads to the exposure of aggregation-prone motifs. Aggregat...
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