The objective was to compare the relative response between rams and bulls in characteristics of LH, FSH and testosterone (T) secretion, during and after long-term treatment with GnRH analogs. Animals were treated with GnRH agonist, GnRH antagonist, or vehicle (Control) for 28 days. Serial blood samples were collected on day 21 of treatment, and at several intervals after treatment. Injections o...

AIMS AND OBJECTIVE To evaluate the role of GnRH antagonist in prevention of premature LH surge and increasing pregnancy rates in IUI cycle with mild ovarian hyperstimulation (MOH). STUDY DESIGN Prospective parallel, randomised controlled study. MATERIAL AND METHODS Couples diagnosed with unexplained, male factor subfertility and with one or both tubes patent were randomised to receive eithe...

Adult male rats received daily injections (sc) of gonadotropin releasing hormone antagonist (0.2 mg/kg(-1) x day(-1)) for 21 days when they were sacrificed on day 22, adrenal weight, adrenal A5-3beta (delta 5-3beta) hydroxysteroid dehydrogenase (Delta5-3beta-HSD) activity and serum level of corticosterone were increased significantly while testicular 17beta (17beta) hydroxysteroid dehydrogenase...

Abstract Study question Could exogenous progestin replace the use of an antagonist GnRH (GNRH-antagonist) without any effects on embryo morphokinetics and implantation rate in freeze-all cycles? Summary answer Exogenous leads to slower development increased cyclés cancellation rate, with when compared cycles using GnRH-antagonist. What is known already Improvements cryopreservation techniques a...

BACKGROUND Little information is available on the outcome of controlled ovarian hyperstimulation (COH) using GnRH antagonist in oocyte donation cycles especially in comparison with the short GnRH agonist protocol. This study was aimed at comparing the two stimulation protocols in oocyte donation (OD) cycles. METHODS A total of 113 donors randomly received COH using either GnRH antagonist or G...

BACKGROUND Coasting can reduce the ovarian hyperstimulation syndrome (OHSS) risk in ovulation induction cycles before intracytoplasmic sperm injection (ICSI). This study aimed to investigate the effect of gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist protocols to controlled ovarian hyperstimulation (COH) cycles with coasting on the parameters of ICSI cycles and the outcome. ...

PCOS is still a problem in gynecology and infertility. Especially in ART the problem of PCOS patients is bigger and more highlighted. These patients are prone to over and under stimulation. Strategies to overcome hyper stimulation are: use of metformin, ovarian drilling, use of minimal stimulation, suppressing LH with use of OCP or GnRh analogues, use of GnRh antagonist in COH. But none of thes...

Increased neuropeptide Y (NPY) activity drives the chronic hyperphagia of lactation and may contribute to the suppression of GnRH activity. The majority of GnRH neurons are contacted by NPY fibers, and GnRH cells express NPY Y5 receptor (Y5R). Therefore, NPY provides a neurocircuitry for information about food intake/energy balance to be directly transmitted to GnRH neurons. To investigate the ...

Abstract Study question Is there an advantage for modified flare/ GnRH antagonist protocol in comparison to oocyte cryopreservation cycles? Summary answer Modified is at least as good cycles, potentially improving maturity rate subgroup of patients. What known already Ultrashort flare agonist (GnRHa)/GnRH -antagonist offer benefits stimulatory effect repeated microdose on endogenous FSH and the...