OBJECTIVES With the advent of new antiparkinsonian drug therapy and promising results from subthalamic and pallidal stimulation, this study evaluated the long term efficacy of unilateral pallidotomy, a technique which has gained popularity over the past decade for the management of advanced Parkinson's disease. METHODS The 15 patients reported here are part of the original cohort of 24 patien...

This debate takes up the question whether concept of »state« can be used meaningfully in context medieval studies. The opening article by Brent D. Shaw addresses political organization Roman empire, and develops a comprehensive argument why even high standards it should regarded as state. six comments Nicola Di Cosmo (Chinese History), Stefano Gasparri Cristina La Rocca, Hans-Werner Goetz, RÃ...

OBJECTIVES New treatments are now becoming available for the management of levodopa induced dyskinesias in Parkinsons's disease. However, assessment of their efficacy is limited by the inadequacies of current methods of dyskinesia measurement. The objective was to develop and validate a portable device capable of objectively measuring dyskinesias during normal daily activities. METHODS A port...

An association between one of the collagen diseases, dermatomyositis, and malignant disease is well recognized; in a recent review Caldwell (1955) states that there are nearly 70 reported cases in which the association has been noted, and an incidence of 18 % malignancy in cases of dermatomyositis has been reported by Curtis, Blaylock, and Harrell (1952). Many authorities (Dowling, 1940; Freude...

There is a link between Oliver Wendell Holmes’ poem “The One-Hoss Shay” (1) and every patient with diabetes who has ever received a kidney or pancreas transplant. Yet, most of the 4,128 diabetes patients in the U.S. who received renal transplants in 2011 (2) and the 1,051 diabetes patients who received a pancreas transplant in 2011 (3) do not know how Dr. Frederick C. Goetz (1922–2012) used thi...