The topology of a SNARE complex bridging two docked vesicles could act as a mechanical couple to do work on the lipid bilayer resulting in fusion. To test this, we prepared a series of modified SNARE proteins and determined their effects on SNARE-dependent membrane fusion. When two helix-breaking proline residues are introduced into the juxtamembrane region of VAMP, there is little or no effect...

peripherally inserted venous ports fracture with embolization in patients who received chemotherapy is a serious and rare complication,and few cases have been reported in children. we report a successful endovascular technique using a snare for retrieving broken peripherally inserted venous ports in a child for chemotherapy. catheter fragments may cause complications such as cardiac perforation...

BACKGROUND AND AIM Cold snare techniques are widely used for the removal of small and diminutive polyps. The influence of snare type on the effectiveness of cold snare polypectomy is unknown. METHODS Cold snare polypectomy of 3-7-mm polyps was undertaken using either a thin wire mini-snare (0.30 mm) or a thick wire mini-snare (0.47 mm). Primary outcome was endoscopic completeness of excision....

Alzheimer's disease (AD) is closely associated with synaptic dysfunction, and thus current treatments often aim to stimulate neurotransmission to improve cognitive impairment. Whereas the formation of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is essential for synaptic transmission, the correlation between SNAREs and AD neuropathology is unknown. H...

Living in society, to go out is almost inevitable for healthy life. There is increasing attention to it in many fields, including pervasive computing, medical science, etc. There are various factors affecting the daily going-out behavior such as the day of the week, the condition of one’s health, and weather. We assume that a person has one’s own rhythm or patterns of going out as a result of t...

Since the discovery and implication of N-ethylmaleimide-sensitive factor (NSF)-attachment protein receptor (SNARE) proteins in membrane fusion almost two decades ago, there have been significant efforts to understand their involvement at the molecular level. In the current study, we report for the first time the molecular interaction between full-length recombinant t-SNAREs and v-SNARE present ...

a 59 year old man is presented with adenocarcinoma of the stomach. in order to evaluate for the presence of the non-lifting sign, methylene blue was injected 2 mm from the perimeter of the tumor. since the tumor lifted, snare removal of the tumor was done, safely. partial gastrectomy was performed 2 weeks after endoscopic removal of the tumor which revealed no residual tumor or lymph node metas...