Gold compounds are among the few therapeutic agents that can cause remission of aggressive rheumatoid arthritis. Although the mechanism for their toxicity and efficacy is unknown, gold levels in blood have been emphasized recently. In this report, we describe a systematic method to study the gold interaction with red blood cells and its distribution in the cell. Flow injection analysis (FIA) an...

The in vitro cytotoxicities of a number of gold(I), silver(I) and copper(I) complexes containing chiral tertiary phosphine ligands have been examined against the mouse tumour cell lines P815 mastocytoma, B16 melanoma [gold(I) and silver(I) compounds] and P388 leukaemia [gold(I) complexes only] with many of the complexes having IC(50) values comparable to that of the reference compounds cis-diam...

In an effort to discover potential alternatives to the anti-cancer drug cisplatin, the synthesis of gold(III) polypyridyl coordination complexes was pursued. Specifically, this report describes the synthesis and characterization of a series of 2,9-dialkyl-1,10-phenanthroline (Rphen) gold(III) coordination complexes (R = n-butyl, sec-butyl, and tert-butyl). Due to the steric hindrance imparted b...

Fifteen commercial titania (titanium(IV) oxide; TiO 2) powders were modified with gold by photodeposition to prepare photocatalysts that work under irradiation with light in the visible range (vis). The gold-modified titania (Au/TiO 2) powders were characterized by diffuse reflectance spectroscopy (DRS), field-emission scanning electron microscopy (FE-SEM), scanning transmission microscopy (STE...

Expensive and explosive! The reaction of ammonia and gold(III) compounds leads to explosive products known as “fulminating gold”. Gold scientists should be aware of the potential hazards involved in the reaction of these starting materials. Herein, a historic and scientific review on this fascinating substance is presented. Fulminating gold has been known since medieval times, but cannot be ful...

Abstract The paper comprises new analytical data on the nature and occurrence of gold in solid pyrobitumen, closely associated with main gold-bearing sulfide arsenic ores Bakyrchik deposit (Kazakhstan), related to post-collisional magmatic-hydrothermal origin. Gold mineralization occurs mainly form an “invisible” type structures arsenian pyrite arsenopyrite, gold-organic compounds pyrobitumen c...

Water-soluble gold(I) complexes [1-mesityl-3-(3-sodiumsulfonatopropyl)imidazol-2-ylidene] gold(I) Chloro (3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene] gold(I) Chloro (4) were prepared, in high yield, by carbene transmetallation from the appropriate NHC silver complex with chloro tetrahydrothiophene gold ([AuCl(tht)]). The antimicrobial properties of both gold(I) c...