background: to enhance the dose to tumor, the use of high atomic number elements has been proposed. objective: the aim of this study is to investigate the effect of gold nanoparticle distribution on dose enhancement in tumor when the tumor is irradiated by typical monoenergetic x-ray beams by considering homogeneous and inhomogeneous distributions of gold nanoparticles (gnps) in the tumor. meth...

We investigate the thermodynamic behavior of a model polymer-grafted nanoparticle (GNP) system on a fine lattice, using grand canonical Monte Carlo simulations, to compare and contrast the validity of two different models for GNPs: "nanoparticle amphiphiles" versus "patchy particles." In the former model, continuous self-assembly processes are expected to dominate the system, whereas the latter...

objective(s):   gold nanoparticles (gnps) command a great deal of attention for biomedical applications nowadays. the data about the degree of toxicity and the accumulation of gold nanoparticles in-vivo is not enough to judge.  materials and methods:  a total of 32 healthy male wistar rats were randomly divided into 4 including: three gnp-treated and one control group. groups 1, 2 and 3 receive...

Electrostatic attraction, covalent binding, and hydrophobic absorption are spontaneous processes to assemble and disassemble the molecules of gold nanoparticles (GNP). This dynamic change can be performed in the presence of ions, such as NaCl or charged molecules. Current research encompasses the GNP in mediating non-biofouling and investigating the molecular attachment and detachment. Experime...

B-Chronic Lymphocytic Leukemia (CLL) is an incurable disease predominantly characterized by apoptosis resistance. We have previously described a VEGF signaling pathway that generates apoptosis resistance in CLL B cells. We found induction of significantly more apoptosis in CLL B cells by co-culture with an anti-VEGF antibody. To increase the efficacy of these agents in CLL therapy we have focus...

The present study aimed to investigate the influence of albumin structure and gold speciation on the synthesis of gold nanoparticles (GNPs). The strategy of synthesis was the addition of HAuCl4 solutions at different pH values (3-12) to solutions of human and bovine serum albumins (HSA and BSA) at the same corresponding pH values. Different pH values influence the GNP synthesis due to gold spec...

INTRODUCTION The present study aimed at evaluating the biodistribution of Tween(®) 20-gold nanoparticle (GNP) conjugates and their potential toxicity on the bone marrow before moving on to Phase I clinical trials. MATERIALS AND METHODS Tween(®) 20-conjugated GNPs were injected intravenously for 21 days in male Crl:CD1(ICR) mice. Body weight of the mice was evaluated each day. After the sub-ch...

Heart failure (HF) has become a major cause of morbidity and mortality with a significant global economic burden. Although well-established clinical tests could provide early diagnosis, access to these tests is limited in developing countries, where a relatively higher incidence of HF is present. This has prompted an urgent need for developing a cost-effective, rapid and robust diagnostic tool ...

In this study, the effects of different ratios graphene nanoparticles (GNP) and Nanofibers on bonding joints were investigated. Therefore, AA5754 alloy samples bonded by adhesive DP460 using nanoparticle Nanofibers. 0.1%, 0.2% 0.3% added to GNP, adhesive. Samples 75x30x3 mm patches 40x30 used, which cut from plate. Tensile tests conducted see each parameter after process. After tension tests, m...